Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor agm-1470

ABSTRACT Angiogenesis, the growth of new blood vessels, occurs normally in female reproductive organs. We tested the hypothesis that angiogenesis inhibition may affect fertility by studying

the reproductive system in either pregnant or nonpregnant cycling mice after treatment with the angiogenesis inhibitor AGM-1470. Administration of AGM-1470 to pregnant mice resulted in

complete failure of embryonic growth due to interference with decidualization, placental and yolk sac formation, and embryonic vascular development. When nonpregnant cycling female mice were

chronically treated with AGM-1470, inhibition of endometrial maturation and corpora lutea was observed. These data suggest that processes in reproduction can be controlled through

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Department of Surgery, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA Nancy Klauber, Richard M. Rohan, Evelyn Flynn & Robert

J. D'amato * Department of Surgery, Boston University Medical Center, Boston, Massachusetts, 02118, USA Nancy Klauber Authors * Nancy Klauber View author publications You can also

search for this author inPubMed Google Scholar * Richard M. Rohan View author publications You can also search for this author inPubMed Google Scholar * Evelyn Flynn View author publications

You can also search for this author inPubMed Google Scholar * Robert J. D'amato View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Klauber, N., Rohan, R., Flynn, E. _et al._ Critical components of the female reproductive pathway are suppressed by

the angiogenesis inhibitor AGM-1470. _Nat Med_ 3, 443–446 (1997). https://doi.org/10.1038/nm0497-443 Download citation * Received: 11 November 1996 * Accepted: 04 February 1997 * Issue Date:

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