Biotech comes to its 'antisenses' after hard-won drug approval
Biotech comes to its 'antisenses' after hard-won drug approval"
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“With any brand new technology, you never know when the world will be ready for it.” So said Paul Boni, an analyst at Punk, Ziegel & Knoll, in 1998 (as quoted by the New York Times), after
the US Food and Drug Administration (FDA) approved its first gene-silencing 'antisense therapy', a drug known as Vitravene (fomivirsen), for the treatment of cytomegalovirus infections in
individuals with weakened immune systems.
The arrival of Vitravene, a short strand of 21 DNA molecular units that blocks viral replication, was hailed as a major milestone for the biotech industry and was widely anticipated to usher
in a new era of antisense products. But no more came. And by the middle of the last decade, Isis Pharmaceuticals, the Carlsbad, California–based company behind Vitravene, ended up pulling
the therapy from the market because improvements in other antiretrovirals had effectively eliminated the drug's target market. Boni's cautionary words proved all too prescient.
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