Biotech comes to its 'antisenses' after hard-won drug approval

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Biotech comes to its 'antisenses' after hard-won drug approval"


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Access through your institution Buy or subscribe “With any brand new technology, you never know when the world will be ready for it.” So said Paul Boni, an analyst at Punk, Ziegel &


Knoll, in 1998 (as quoted by the _New York Times_), after the US Food and Drug Administration (FDA) approved its first gene-silencing 'antisense therapy', a drug known as Vitravene


(fomivirsen), for the treatment of cytomegalovirus infections in individuals with weakened immune systems. The arrival of Vitravene, a short strand of 21 DNA molecular units that blocks


viral replication, was hailed as a major milestone for the biotech industry and was widely anticipated to usher in a new era of antisense products. But no more came. And by the middle of the


last decade, Isis Pharmaceuticals, the Carlsbad, California–based company behind Vitravene, ended up pulling the therapy from the market because improvements in other antiretrovirals had


effectively eliminated the drug's target market. Boni's cautionary words proved all too prescient. This is a preview of subscription content, access via your institution RELEVANT


ARTICLES Open Access articles citing this article. * DNA/RNA HETERODUPLEX OLIGONUCLEOTIDE FOR HIGHLY EFFICIENT GENE SILENCING * Kazutaka Nishina * , Wenying Piao *  … Takanori Yokota _Nature


Communications_ Open Access 10 August 2015 * MERKEL CELL CARCINOMA: EPIDEMIOLOGY, TARGET, AND THERAPY * Mathew P. Hughes * , Matthew E. Hardee *  … Ling Gao _Current Dermatology Reports_


Open Access 22 January 2014 ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn


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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Kevin Jiang View author publications You can also search for this author


inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jiang, K. Biotech comes to its 'antisenses' after hard-won drug


approval. _Nat Med_ 19, 252 (2013). https://doi.org/10.1038/nm0313-252 Download citation * Published: 06 March 2013 * Issue Date: March 2013 * DOI: https://doi.org/10.1038/nm0313-252 SHARE


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