The pull of the prions | Nature Medicine

Access through your institution Buy or subscribe Misfolded prion protein causes the buildup of voltage-gated calcium channels inside the cell, interfering with normal neuronal communication

and causing motor dysfunction, according to a recent study (_Neuron_ 74, 300–313). Mutations in the _PRNP_ gene can lead to PrP protein aggregation and can cause a variety of neurological

diseases in humans that are commonly linked to motor dysfunction. Assunta Senatore _et al_. found that, compared with mice expressing wild-type PrP, mice expressing mutant PrP showed

reductions in glutamate release at synapses in the cerebellum, a part of the brain that controls motor function. This is a preview of subscription content, access via your institution ACCESS

OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on

SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about

institutional subscriptions * Read our FAQs * Contact customer support Authors * Eva Chmielnicki View author publications You can also search for this author inPubMed Google Scholar RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Chmielnicki, E. The pull of the prions. _Nat Med_ 18, 868 (2012). https://doi.org/10.1038/nm.2836 Download

citation * Published: 06 June 2012 * Issue Date: June 2012 * DOI: https://doi.org/10.1038/nm.2836 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative