Response of naïve and memory cd8+ t cells to antigen stimulation in vivo

ABSTRACT We studied the influence of memory T cell properties on the efficiency of secondary immune responses by comparing the _in vivo_ immune response of the same numbers of T cell

receptor (TCR) transgenic (Tg) naïve and memory T cells. Compared to naïve Tg cells, memory cells divided after a shorter lag time; had an increased division rate; a lower loss rate; and

showed more rapid and efficient differentiation to effector functions. We found that initial naïve T cell priming resulted in cells expressing mutually exclusive effector functions, whereas

memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector functions simultaneously. These special properties of memory T

cells ensure the immediate control of reinfection. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS PRECURSORS OF EXHAUSTED T CELLS ARE PRE-EMPTIVELY FORMED IN ACUTE INFECTION

Article Open access 08 January 2025 ‘STEM-LIKE’ PRECURSORS ARE THE FOUNT TO SUSTAIN PERSISTENT CD8+ T CELL RESPONSES Article 27 May 2022 CD4+ T CELL MEMORY Article 08 May 2023 REFERENCES *

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Le Campion for statistics; J. Di Santo, A.A. Freitas, D. Guy-Grand, A. Sarukhan and H. von Boehmer for reviewing the manuscript. This work was supported by grants from the National

Association of AIDS Research, France. H.V.-F. was supported by a grant from Technology and Science Foundation, Praxis XXI, Portugal. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * INSERM

U.345, Paris, France Henrique Veiga-Fernandes, Christine Bourgeois & Benedita Rocha * U373, Institut Necker, Paris, France Ulrich Walter * Institute for Animal Health, Compton, UK Angela

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Response of naïve and memory CD8+ T cells to antigen stimulation _in vivo_. _Nat Immunol_ 1, 47–53 (2000). https://doi.org/10.1038/76907 Download citation * Received: 23 March 2000 *

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