Fueling IgA production | Nature Immunology

Access through your institution Buy or subscribe Intestinal microbiota and their metabolites can regulate both local and systemic immunity. In _Cell Host and Microbe_, Kim and colleagues

find that short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fiber modulate the production of immunoglobulin A (IgA) in the gut. Mice fed low-fiber diets generate

fewer IgA+ B cells and IgA-producing plasma cells in a microbiota-dependent manner. Administration of SCFAs themselves produces a similar effect through an increase in IgA production and

directly skews the B cell transcriptional program toward antibody production, probably through the deacetylase-inhibitory activity of SCFAs. Another important function of the SCFAs is their

help in driving the metabolically demanding activity of class switching and antibody synthesis by boosting B cell glycolysis. A diet rich in fiber and SCFAs helps to support an effective

IgA-mediated response to the gut pathogen _Citrobacter rodentium_. _Cell Host Microbe_ 20, 202–214 (2016) This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support Authors * Zoltan Fehervari View author publications You can also search for this author inPubMed Google Scholar RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fehervari, Z. Fueling IgA production. _Nat Immunol_ 17, 1141 (2016). https://doi.org/10.1038/ni.3570 Download

citation * Published: 20 September 2016 * Issue Date: October 2016 * DOI: https://doi.org/10.1038/ni.3570 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

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