Reining in uncontrolled inflammasome with pka

New findings show that the NLRP3 inflammasome is inactivated by disassembly of the inflammasome mediated by the kinase PKA and that this regulation might be negated in NLRP3-gain-of-function

diseases. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to

this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy

now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact

customer support REFERENCES * Guo, H., Callaway, J.B. & Ting, J.P. _Nat. Med._ 21, 677–687 (2015). Article  Google Scholar  * Lamkanfi, M. & Dixit, V.M. _Cell_ 157, 1013–1022 (2014).

Article  CAS  Google Scholar  * Mortimer, L., Moreau, F., MacDonald, J.A. & Chadee, K. _Nat. Immunol._ 17, 1176–1186 (2106). Article  Google Scholar  * Takeuchi, O. & Akira, S.

_Cell_ 140, 805–820 (2010). Article  CAS  Google Scholar  * Kayagaki, N. et al. _Nature_ 479, 117–121 (2011). Article  CAS  Google Scholar  * Yang, J., Liu, Z. & Xiao, T.S. _Cell. Mol.

Immunol._ http://dx.doi.org/10.1038/cmi.2016.29 (27 June 2016). * Latz, E., Xiao, T.S. & Stutz, A. _Nat. Rev. Immunol._ 13, 397–411 (2013). Article  CAS  Google Scholar  * Brandwein,

S.R. _J. Biol. Chem._ 261, 8624–8632 (1986). CAS  PubMed  Google Scholar  * Lee, G.S. et al. _Nature_ 492, 123–127 (2012). Article  CAS  Google Scholar  * Sokolowska, M. et al. _J. Immunol._

194, 5472–5487 (2015). Article  CAS  Google Scholar  * Yan, Y. et al. _Cell_ 160, 62–73 (2015). Article  CAS  Google Scholar  * Duncan, J.A. et al. _Proc. Natl. Acad. Sci. USA_ 104,

8041–8046 (2007). Article  CAS  Google Scholar  * Broderick, L., De Nardo, D., Franklin, B.S., Hoffman, H.M. & Latz, E. _Annu. Rev. Pathol._ 10, 395–424 (2015). Article  CAS  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * and the Department of Genetics, Karen V. Swanson is with the Lineberger Comprehensive Cancer Center, University of

North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Karen V Swanson * the Department of Genetics,

Jenny P.-Y. Ting is with the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, University of North Carolina at Chapel

Hill, Chapel Hill, North Carolina, USA, the Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, and the Institute for

Inflammatory Diseases, University of North Carolina at Chapel Hill, North Carolina, USA., Jenny P-Y Ting Authors * Karen V Swanson View author publications You can also search for this

author inPubMed Google Scholar * Jenny P-Y Ting View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jenny P-Y Ting.

ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Swanson,

K., Ting, JY. Reining in uncontrolled inflammasome with PKA. _Nat Immunol_ 17, 1137–1138 (2016). https://doi.org/10.1038/ni.3556 Download citation * Published: 20 September 2016 * Issue

Date: October 2016 * DOI: https://doi.org/10.1038/ni.3556 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative