Microbiota-induced priming | Nature Immunology

Access through your institution Buy or subscribe How specific components of the microbiota, such as _Clostridium_ and SFB, modulate the homeostasis of regulatory T cells and the TH17 subset

of helper T cells remains unknown. In _Immunity_, Ivanov and colleagues show that SFB induce TH17 cells in a manner dependent on SFB-derived antigens and that intestinal CD11c+ dendritic

cells (DCs) are necessary and sufficient for this process. The induction of TH17 cells by SFB in the lamina propria requires the expression of major histocompatibility complex class II. An

SFB-conditioned intestinal environment does not induce IL-17 expression in non–SFB-specific transgenic T cells. Lamina propria TH17 cells from SFB-colonized mice, but not those from

SFB-negative mice, respond strongly and specifically to SFB-derived antigens, whereas non-TH17 cells do not. The response is diverse and polyclonal. Peyer's patches or mesenteric lymph

nodes are not required for the induction of TH17 cells by SFB, which suggests that DCs prime the CD4+ T cells locally in the lamina propria. _Immunity_ 40, 594–607 (2014) This is a preview

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Ioana Visan View author publications You can also search

for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Visan, I. Microbiota-induced priming. _Nat Immunol_ 15, 537

(2014). https://doi.org/10.1038/ni.2907 Download citation * Published: 19 May 2014 * Issue Date: June 2014 * DOI: https://doi.org/10.1038/ni.2907 SHARE THIS ARTICLE Anyone you share the

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