Strategies to determine the biological function of micrornas

ABSTRACT MicroRNAs (miRNAs) are regulators of gene expression that control many biological processes in development, differentiation, growth and metabolism. Their expression levels, small

size, abundance of repetitive copies in the genome and mode of action pose unique challenges in studies elucidating the function of miRNAs. New technologies for identification, expression

profiling and target gene validation, as well as manipulation of miRNA expression _in vivo_, will facilitate the study of their contribution to biological processes and disease. Such

information will be crucial to exploit the emerging knowledge of miRNAs for the development of new human therapeutic applications. Access through your institution Buy or subscribe This is a

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NON-EXISTENT “MICRORNAS” IN CANCER Article Open access 18 April 2025 THE ROLES OF MICRORNAS IN MOUSE DEVELOPMENT Article 15 January 2021 MICRORNA-184 IN THE LANDSCAPE OF HUMAN MALIGNANCIES:

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ADAR deaminases. _Nat. Struct. Mol. Biol._ 13, 13–21 (2006). Article  CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Metabolic

Diseases, The Rockefeller University, 1230 York Avenue, New York, 10021, New York, USA Jan Krützfeldt, Matthew N Poy & Markus Stoffel Authors * Jan Krützfeldt View author publications

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publications You can also search for this author inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS M.S. is a member of the Scientific Advisory Board of Aluylam Pharmaceuticals.

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_Nat Genet_ 38 (Suppl 6), S14–S19 (2006). https://doi.org/10.1038/ng1799 Download citation * Published: 30 May 2006 * Issue Date: June 2006 * DOI: https://doi.org/10.1038/ng1799 SHARE THIS

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