Il4r mutations predict erosive disease in rheumatoid arthritis

Access through your institution Buy or subscribe Prots I _ et al_. (2006) Association of the _IL4R_ single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis. _Arthritis

Rheum_ 54: 1491–1500 Early treatment of inflammation in patients with rheumatoid arthritis (RA) is thought to limit the progression of joint destruction, so prompt identification of patients

at risk of developing erosive disease is important. Genome-wide studies have suggested that the interleukin 4 receptor (_IL4R_) gene is associated with susceptibility to and/or progression

of disease in RA. Prots _ et al_. investigated the influence of two known single nucleotide polymorphisms in _IL4R_ (the resulting amino-acid substitutions Ile50Val and Gln551Arg cause

functional changes in its product, IL-4R) on RA susceptibility and progression. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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_Nat Rev Rheumatol_ 2, 405 (2006). https://doi.org/10.1038/ncprheum0239 Download citation * Issue Date: August 2006 * DOI: https://doi.org/10.1038/ncprheum0239 SHARE THIS ARTICLE Anyone you

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