Sequence-controlled methacrylic multiblock copolymers via sulfur-free raft emulsion polymerization

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Sequence-controlled methacrylic multiblock copolymers via sulfur-free raft emulsion polymerization"


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ABSTRACT Translating the precise monomer sequence control achieved in nature over macromolecular structure (for example, DNA) to whole synthetic systems has been limited due to the lack of


efficient synthetic methodologies. So far, chemists have only been able to synthesize monomer sequence-controlled macromolecules by means of complex, time-consuming and iterative chemical


strategies such as solid-state Merrifield-type approaches or molecularly dissolved solution-phase systems. Here, we report a rapid and quantitative synthesis of sequence-controlled


multiblock polymers in discrete stable nanoscale compartments via an emulsion polymerization approach in which a vinyl-terminated macromolecule is used as an efficient chain-transfer agent.


This approach is environmentally friendly, fully translatable to industry and thus represents a significant advance in the development of complex macromolecule synthesis, where a high level


of molecular precision or monomer sequence control confers potential for molecular targeting, recognition and biocatalysis, as well as molecular information storage. Access through your


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BEING VIEWED BY OTHERS ONE-STEP SYNTHESIS OF SEQUENCE-CONTROLLED MULTIBLOCK POLYMERS WITH UP TO 11 SEGMENTS FROM MONOMER MIXTURE Article Open access 10 January 2022 CONCURRENT CONTROL OVER


SEQUENCE AND DISPERSITY IN MULTIBLOCK COPOLYMERS Article 29 November 2021 POLYMER CYCLIZATION FOR THE EMERGENCE OF HIERARCHICAL NANOSTRUCTURES Article Open access 25 June 2021 REFERENCES *


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412–420 (2010). Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS The authors acknowledge financial support from the University of Warwick, the Australian Research


Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036) and Lubrizol (to N.G.E.). D.M.H. is a Wolfson/Royal Society Research Fellow. The authors


acknowledge the facilities and personnel (A.A., M.R.W., T.P.D. and D.M.H.) enabled by the Monash–Warwick Alliance. AUTHOR INFORMATION Author notes * Nikolaos G. Engelis and Athina


Anastasaki: These authors contributed equally to this work AUTHORS AND AFFILIATIONS * Chemistry Department, University of Warwick, Library Road, Coventry, CV4 7AL, UK Nikolaos G. Engelis, 


Athina Anastasaki, Gabit Nurumbetov, Vasiliki Nikolaou, Ataulla Shegiwal, Thomas P. Davis & David M. Haddleton * ARC Centre of Excellence in Convergent Bio-Nano Science and Technology,


Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 399 Royal Parade, Parkville, 3152, Victoria, Australia Athina Anastasaki, Nghia P. Truong, Michael R.


Whittaker, Thomas P. Davis & David M. Haddleton Authors * Nikolaos G. Engelis View author publications You can also search for this author inPubMed Google Scholar * Athina Anastasaki


View author publications You can also search for this author inPubMed Google Scholar * Gabit Nurumbetov View author publications You can also search for this author inPubMed Google Scholar *


Nghia P. Truong View author publications You can also search for this author inPubMed Google Scholar * Vasiliki Nikolaou View author publications You can also search for this author


inPubMed Google Scholar * Ataulla Shegiwal View author publications You can also search for this author inPubMed Google Scholar * Michael R. Whittaker View author publications You can also


search for this author inPubMed Google Scholar * Thomas P. Davis View author publications You can also search for this author inPubMed Google Scholar * David M. Haddleton View author


publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS A.A., D.M.H. and T.P.D. conceived and designed the experiments. N.G.E. and A.A. performed the


experiments. N.G.E., A.A., and V.N. analysed the data with input from G.N, N.P.T., A.S. and M.R.W. A.A. and N.G.E. co-wrote the paper. All authors discussed the results and commented on the


manuscript. A.A. and N.G.E. contributed equally to this work. CORRESPONDING AUTHORS Correspondence to Athina Anastasaki, Thomas P. Davis or David M. Haddleton. ETHICS DECLARATIONS COMPETING


INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION Supplementary information (PDF 2168 kb) RIGHTS AND PERMISSIONS Reprints


and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Engelis, N., Anastasaki, A., Nurumbetov, G. _et al._ Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion


polymerization. _Nature Chem_ 9, 171–178 (2017). https://doi.org/10.1038/nchem.2634 Download citation * Received: 22 February 2016 * Accepted: 02 September 2016 * Published: 17 October 2016


* Issue Date: February 2017 * DOI: https://doi.org/10.1038/nchem.2634 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry,


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