Regulation of gene expression in vivo following transduction by two separate rAAV vectors
Regulation of gene expression in vivo following transduction by two separate rAAV vectors"
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Control of gene expression is important to gene therapy for purposes of both dosing and safety. In vivo regulation of gene expression was demonstrated following co-injection of two separate
recombinant adeno-associated virus vectors, one encoding an inducible murine erythropoietin transgene and the other a transcriptional activator, directly into the skeletal muscle of adult
immunocompetent mice. Transcription was controlled by systemic administration or withdrawal of tetracycline over an 18 week period, demonstrating that the two vectors were capable of
transducing the same cell. Cellular or humoral immune responses against the transactivator protein were not detected.
Katherine G. Rendahl, Stuart E. Leff, Gillis R. Otten, Melinda Van Roey, Brian A. Donahue, Ronald J. Mandel & Richard O. Snyder
Institut Pasteur, Laboratoire RTC, Dept. SIDA/Retrovirus, 75015, Paris, France
S. Kaye Spratt, Delphine Bohl, Lawrence K. Cohen & Olivier Danos
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