Oncogenes, cell cycle genes and the control of cell proliferation

ABSTRACT The reproduction of animal cells is regulated by growth factors in the environment and the gene and gene products that respond to and interact with these growth factors. The genes

that play a role in cell reproduction can be grouped under the term of growth–related genes and include cellular oncogenes, wild type alleles of cell cycle mutants and growth–regulated

genes. The extent of cell proliferation in a population of cells is determined largely at the G0–G1 interface. Although it has been customary to study the regulation of cell proliferation in

the early stages of the G0 to S transition, evidence seems to indicate we have been looking in the wrong place and the critical, proliferation–specific events may occur in mid or late G1.

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support SIMILAR CONTENT BEING VIEWED BY OTHERS EMERGING MECHANISMS OF CELL COMPETITION Article 10 August 2020 MODELING HOMEOSTASIS MECHANISMS THAT SET THE TARGET CELL SIZE Article Open

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and platelet-derived growth factor. _Cell._ 35: 603–610. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology and Fels

Research Institute, Temple University Medical School, Philadelphia, PA, 19140 Renato Baserga & Ewa Surmacz Authors * Renato Baserga View author publications You can also search for this

author inPubMed Google Scholar * Ewa Surmacz View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Baserga, R., Surmacz, E. Oncogenes, Cell Cycle Genes and the Control of Cell Proliferation. _Nat Biotechnol_ 5, 355–358 (1987). https://doi.org/10.1038/nbt0487-355

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