The nexus of chromatin regulation and intermediary metabolism

ABSTRACT Living organisms and individual cells continuously adapt to changes in their environment. Those changes are particularly sensitive to fluctuations in the availability of energy

substrates. The cellular transcriptional machinery and its chromatin-associated proteins integrate environmental inputs to mediate homeostatic responses through gene regulation. Numerous

connections between products of intermediary metabolism and chromatin proteins have recently been identified. Chromatin modifications that occur in response to metabolic signals are dynamic

or stable and might even be inherited transgenerationally. These emerging concepts have biological relevance to tissue homeostasis, disease and ageing. Access through your institution Buy or

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THE EVOLVING METABOLIC LANDSCAPE OF CHROMATIN BIOLOGY AND EPIGENETICS Article 09 September 2020 HETEROCHROMATIN: AN EPIGENETIC POINT OF VIEW IN AGING Article Open access 04 September 2020

NUCLEAR METABOLISM AND THE REGULATION OF THE EPIGENOME Article 12 October 2020 CHANGE HISTORY * _ 10 DECEMBER 2013 The TCA cycle in Figure 2 has been corrected in the online version of this

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Lucido for editorial assistance, V. Fonseca and P. Cruz for administrative assistance. The authors are supported by funds from the Gladstone Institutes. AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Gladstone Institutes, University of California, San Francisco, 94941, California, USA Philipp Gut & Eric Verdin Authors * Philipp Gut View author publications You can also

search for this author inPubMed Google Scholar * Eric Verdin View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Eric

Verdin. ETHICS DECLARATIONS COMPETING INTERESTS E.V. is a member of the scientific advisory board of SIRTRIS/GSK ADDITIONAL INFORMATION Reprints and permissions information is available at

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metabolism. _Nature_ 502, 489–498 (2013). https://doi.org/10.1038/nature12752 Download citation * Received: 15 March 2013 * Accepted: 16 August 2013 * Published: 23 October 2013 * Issue

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