Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis

Access through your institution Buy or subscribe We read an article written by Wolley _et al._1 with interest. We found that treatment of primary aldosteronism by adrenalectomy or

aldosterone antagonists was associated with a reduction in the severity of obstructive sleep apnoea (OSA). Although resistant hypertension (RH) is highly prevalent in patients with OSA and

hyperaldosteronism, the authors did not recruit participants with RH. We completed a meta-analysis to assess the effect of aldosterone antagonists on OSA in patients with RH. We searched

PubMed, Embase, Web of Science and Cochrane Database until June 2017. Studies were included if they met the following criteria:1 studies primarily aimed to evaluate the effect of aldosterone

antagonists on OSA;2 included participants with RH. Case reports, reviews, conference abstracts and experiments were excluded. Review Manager 5.3 (Cochrane Collaboration, Oxford, UK) was

used for all statistical analyses. Random-effects models were applied to synthesize data across studies. Median (interquartile range) was used to conservatively estimate mean±s.d. via the

formula provided in _Cochrane Handbook for Systematic Reviews of Interventions_. _P_<0.05 was considered significant. This is a preview of subscription content, access via your

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Wolley MJ, Pimenta E, Calhoun D, Gordon RD, Cowley D, Stowasser M . Treatment of

primary aldosteronism is associated with a reduction in the severity of obstructive sleep apnoea. _J Hum Hypertens_ 2017; 31 (9): 561–567. Article  CAS  PubMed  Google Scholar  * Gaddam K,

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INFORMATION AUTHORS AND AFFILIATIONS * Department of Cardiology, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China W-D Zhang, J-W Zhang, K-F Wu, 

Y-P Wang, L-H Zhou, H-T Wang & S-M Chen * Medical College of Shantou University, Shantou, Guangdong, China W-D Zhang & X Chen Authors * W-D Zhang View author publications You can

also search for this author inPubMed Google Scholar * J-W Zhang View author publications You can also search for this author inPubMed Google Scholar * K-F Wu View author publications You can

also search for this author inPubMed Google Scholar * X Chen View author publications You can also search for this author inPubMed Google Scholar * Y-P Wang View author publications You can

also search for this author inPubMed Google Scholar * L-H Zhou View author publications You can also search for this author inPubMed Google Scholar * H-T Wang View author publications You

can also search for this author inPubMed Google Scholar * S-M Chen View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to

S-M Chen. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zhang,

WD., Zhang, JW., Wu, KF. _et al._ Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis. _J Hum

Hypertens_ 31, 855–856 (2017). https://doi.org/10.1038/jhh.2017.70 Download citation * Published: 21 September 2017 * Issue Date: December 2017 * DOI: https://doi.org/10.1038/jhh.2017.70

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