Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis
Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis"
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We read an article written by Wolley et al.1 with interest. We found that treatment of primary aldosteronism by adrenalectomy or aldosterone antagonists was associated with a reduction in
the severity of obstructive sleep apnoea (OSA). Although resistant hypertension (RH) is highly prevalent in patients with OSA and hyperaldosteronism, the authors did not recruit participants
with RH. We completed a meta-analysis to assess the effect of aldosterone antagonists on OSA in patients with RH.
We searched PubMed, Embase, Web of Science and Cochrane Database until June 2017. Studies were included if they met the following criteria:1 studies primarily aimed to evaluate the effect of
aldosterone antagonists on OSA;2 included participants with RH. Case reports, reviews, conference abstracts and experiments were excluded. Review Manager 5.3 (Cochrane Collaboration,
Oxford, UK) was used for all statistical analyses. Random-effects models were applied to synthesize data across studies. Median (interquartile range) was used to conservatively estimate
mean±s.d. via the formula provided in Cochrane Handbook for Systematic Reviews of Interventions. P
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Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysisWe read an article written by Wolley et al.1 with interest. We found that treatment of primary aldosteronism by adrenale...
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