Genetic variations in five genes involved in the excitement of cardiomyocytes

ABSTRACT We provide here 29 genetic variations, including 28 novel ones, in five genes that are potentially involved in the excitement of cardiomyocytes: we found 4 in _KCNA10_, 2 in

_KCNK1_, 8 in _KCNK6_, 11 in _SLC18A1_ (VMAT1), and 4 in _SLC6A2_ (norepinephrine transporter). We also examined their allelic frequencies in a Japanese population of long QT

syndrome-affected and nonaffected individuals. These data would be useful for genetic association studies designed to investigate acquired arrhythmias. SIMILAR CONTENT BEING VIEWED BY OTHERS

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OF SODIUM CHANNEL REGULATION IN DISEASE SUSCEPTIBILITY Article 24 February 2022 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratory of Molecular Medicine, Human Genome

Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan Tel. +81-3-5449-5375; Fax +81-3-5449-5406 e-mail: [email protected],

, , , , , JP H. Iwasa, Y. Nakamura & T. Tanaka * Second Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan, , , , , , JP M. Kurabayashi * Department of

Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, , , , , , JP R. Nagai Authors * H. Iwasa View author publications You can also search for this author

inPubMed Google Scholar * M. Kurabayashi View author publications You can also search for this author inPubMed Google Scholar * R. Nagai View author publications You can also search for

this author inPubMed Google Scholar * Y. Nakamura View author publications You can also search for this author inPubMed Google Scholar * T. Tanaka View author publications You can also

search for this author inPubMed Google Scholar ADDITIONAL INFORMATION Received: May 22, 2001 / Accepted: June 8, 2001 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Iwasa, H., Kurabayashi, M., Nagai, R. _et al._ Genetic variations in five genes involved in the excitement of cardiomyocytes. _J Hum Genet_ 46, 549–552 (2001).

https://doi.org/10.1007/s100380170039 Download citation * Issue Date: September 2001 * DOI: https://doi.org/10.1007/s100380170039 SHARE THIS ARTICLE Anyone you share the following link with

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content-sharing initiative * Key words Long QT syndrome * Single-nucleotide polymorphism * Japanese population * Norepinephrine transporter * VMAT1 * Two-pore domain potassium channel *

KCNA10