Inhibition of matrix metalloproteinase-9 activity by trandolapril after middle cerebral artery occlusion in rats

ABSTRACT We investigated whether an angiotensin-converting enzyme (ACE) inhibitor could inhibit matrix metalloproteinase (MMP) activities in cerebral infarct lesions after middle cerebral

artery occlusion (MCAO) in rats. After placebo or trandolapril (5 mg/kg per day) was administered orally for 7 days, we permanently occluded the right middle cerebral artery. ACE activity in

extracts from the infarct side of placebo-treated rats was significantly higher than that in extracts from the non-infarct side from 5 days after MCAO, though they did not differ at 1 day.

ACE activities in extracts from both hemispheric segments in the trandolapril-treated group were significantly decreased compared with those in the placebo-treated group before MCAO, and

this significant reduction persisted even at 7 days after MCAO. In the placebo-treated group, MMP-9 and MMP-2 activities in the infarct side were significantly increased at 12 h and at 1 day

after MCAO, respectively. Trandolapril treatment significantly reduced MMP-9 and MMP-2 activities to 68.5% and 53.2%, respectively. Seven days after MCAO, the ratios of infarct areas to the

hemispheric sectional areas in placebo- and trandolapril-treated rats were 55.4±2.1% and 30.9±2.9%, respectively, and this difference was significant. Neurological severity scores were

significantly improved from 1 to 7 days after MCAO in trandolapril-treated rats. Cumulative survival in trandolapril-treated rats was significantly increased compared with that in

placebo-treated rats. Thus, the inhibition of MMP-9 by trandolapril might be part of the mechanism that prevents cerebral damage after cerebral ischemia. SIMILAR CONTENT BEING VIEWED BY

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THE COMBINATION OF DANTROLENE AND NIMODIPINE EFFECTIVELY REDUCES 5-HT-INDUCED VASOSPASMS IN DIABETIC RATS Article Open access 10 May 2021 ARTICLE PDF REFERENCES * Fukuhara M, Geary RL, Diz

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460–467. Article  CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan Hidekazu

Tanaka, Yoshinaga Kajimoto, Shin-Ichi Miyatake & Toshihiko Kuroiwa * Department of Pharmacology, Osaka Medical College, Takatsuki, Japan Shinji Takai, Denan Jin, Keiichi Furubayashi, Nao

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View author publications You can also search for this author inPubMed Google Scholar * Shin-Ichi Miyatake View author publications You can also search for this author inPubMed Google

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inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Shinji Takai. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tanaka, H., Takai, S., Jin,

D. _et al._ Inhibition of Matrix Metalloproteinase-9 Activity by Trandolapril after Middle Cerebral Artery Occlusion in Rats. _Hypertens Res_ 30, 469–475 (2007).

https://doi.org/10.1291/hypres.30.469 Download citation * Received: 09 November 2006 * Accepted: 20 December 2006 * Issue Date: 01 May 2007 * DOI: https://doi.org/10.1291/hypres.30.469 SHARE

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * angiotensin converting enzyme * cerebral infarction * macrophage * inhibitor