Effects of eplerenone and salt intake on left ventricular remodeling after myocardial infarction in rats

ABSTRACT Eplerenone, a selective aldosterone blocker, has been shown to attenuate cardiac fibrosis and decrease cardiovascular events in both experimental and clinical studies. We examined

the cardioprotective effect of eplerenone in myocardial infarction (MI) rats receiving different levels of salt in their diet. The MI rats were randomly divided into five groups: Group CL,

animals received a low-salt diet (0.015%); Group EpL, a low-salt diet with eplerenone (100 mg/kg/day in food); Group CH, a high-salt diet (0.9%); Group EpH, a high-salt diet with eplerenone;

and Group C, a normal salt diet (0.3%). These diets were continued for 4 weeks. Echocardiographic and histomorphological examinations revealed that the administration of eplerenone

significantly improved the cardiac function, significantly suppressed compensatory cardiac hypertrophy and significantly reduced cardiac fibrosis in both the interstitial and the

perivascular areas in the high-salt diet group (Group EpH). However, eplerenone had no observable effects in the low-salt diet group (Group EpL). Also, these examinations demonstrated that

the left ventricular remodeling after MI was suppressed and the cardiac function was improved in the group receiving a low-salt diet without eplerenone (Group CL), even though there was a

significant increase of aldosterone level in blood, in comparison to the group receiving a high-salt diet without eplerenone (Group CH). These results indicate that the cardioprotective

effect of eplerenone varies depending on the salt intake. SIMILAR CONTENT BEING VIEWED BY OTHERS COMPARISON OF THE EFFECTS OF RENAL DENERVATION AT EARLY OR ADVANCED STAGES OF HYPERTENSION ON

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Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Cardiology, Department of Internal Medicine, the Jikei University School of Medicine, Tokyo,

Japan Akihiro Urabe, Takehiko Izumi, Yuichi Abe, Ikuo Taniguchi & Seibu Mochizuki Authors * Akihiro Urabe View author publications You can also search for this author inPubMed Google

Scholar * Takehiko Izumi View author publications You can also search for this author inPubMed Google Scholar * Yuichi Abe View author publications You can also search for this author

inPubMed Google Scholar * Ikuo Taniguchi View author publications You can also search for this author inPubMed Google Scholar * Seibu Mochizuki View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Akihiro Urabe. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Urabe, A.,

Izumi, T., Abe, Y. _et al._ Effects of Eplerenone and Salt Intake on Left Ventricular Remodeling after Myocardial Infarction in Rats. _Hypertens Res_ 29, 627–634 (2006).

https://doi.org/10.1291/hypres.29.627 Download citation * Received: 21 February 2006 * Accepted: 18 April 2006 * Issue Date: 01 August 2006 * DOI: https://doi.org/10.1291/hypres.29.627 SHARE

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * selective aldosterone blocker * salt intake * left ventricular remodeling * myocardial infarction