Effects of l-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial

ABSTRACT BACKGROUND/OBJECTIVES: Pemphigus vulgaris (PV), as an autoimmune disease including mucosa and the skin, is associated with several complications and comorbidities. The present study

planned to determine the effect of L-carnitine (LC) supplementation on biomarkers of oxidative stress (OS), antioxidant capacity and lipid profile in PV patients. SUBJECTS/METHODS Fifty two

control and patients with PV, participated in the current randomized, double-blind, placebo-controlled clinical trial. The patients were allocated randomly to receive 2 g per day LC

tartrate subdivided into two equal doses of 1 g before breakfast and dinner (_n_=26) or placebo (_n_=26) for 8 weeks. Anthropometric, lipid profile and OS values were determined at baseline

and end of intervention period. RESULTS: LC intake significantly reduced serum levels of triglycerides, total-, LDL- cholesterol and oxidative stress index (OSI; _P_<0.05). In addition,

supplementation with LC resulted to a meaningful increase in levels of total antioxidant capacity (TAC) (_P_=0.05) and serum carnitine (_P_<0.001). LC intake revealed non-significant

change in serum total oxidant capacity (_P_=0.15) and HDL- cholesterol (_P_=0.06) in comparison to the placebo. CONCLUSIONS: LC consumption may have favorable results on TAC, OSI and lipid

profiles in patients with PV. The results were in line with the idea that LC supplementation can be associated with positive effects on metabolic status and OS of patients with PV. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS HIGH DIETARY ACID LOAD PREDICTS SEVERITY OF AUTOIMMUNE SKIN DISEASE: A CROSS-SECTIONAL STUDY Article Open access 04 December 2024 EFFECTIVENESS OF DATE

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ACKNOWLEDGEMENTS This work is a part of MSc thesis supported by by the grants from TUMS (No.28824). We are thankful to all patients who contributed dedicatedly in the study. AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran H

Mohammadi, M Djalali, N M Honarvar, F Sepandar, Z Fakhri, E Yaghubi, M Zarei & M H Javanbakht * Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University

of Medical Sciences, Tehran, Iran M Daneshpazhooh & C Chams‐Davatchi Authors * H Mohammadi View author publications You can also search for this author inPubMed Google Scholar * M

Djalali View author publications You can also search for this author inPubMed Google Scholar * M Daneshpazhooh View author publications You can also search for this author inPubMed Google

Scholar * N M Honarvar View author publications You can also search for this author inPubMed Google Scholar * C Chams‐Davatchi View author publications You can also search for this author

inPubMed Google Scholar * F Sepandar View author publications You can also search for this author inPubMed Google Scholar * Z Fakhri View author publications You can also search for this

author inPubMed Google Scholar * E Yaghubi View author publications You can also search for this author inPubMed Google Scholar * M Zarei View author publications You can also search for

this author inPubMed Google Scholar * M H Javanbakht View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to M H

Javanbakht. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. ADDITIONAL INFORMATION Supplementary Information accompanies this paper on European Journal

of Clinical Nutrition website SUPPLEMENTARY INFORMATION SUPPLEMENTARY TABLE S1 (DOCX 14 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mohammadi,

H., Djalali, M., Daneshpazhooh, M. _et al._ Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus

vulgaris: a randomized, double-blind, placebo-controlled trial. _Eur J Clin Nutr_ 72, 99–104 (2018). https://doi.org/10.1038/ejcn.2017.131 Download citation * Received: 07 November 2016 *

Revised: 02 July 2017 * Accepted: 18 July 2017 * Published: 23 August 2017 * Issue Date: January 2018 * DOI: https://doi.org/10.1038/ejcn.2017.131 SHARE THIS ARTICLE Anyone you share the

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