Atypical presentation of progressive multifocal leukoencephalopathy in a multiple myeloma patient after auto-sct successfully treated with combination therapy

Access through your institution Buy or subscribe We read with interest the article by Kharfan-Dabaja _et al._1 on two cases of fatal progressive multifocal leukoencephalopathy (PML) that

developed after SCT. We report on a patient who developed this type of complication after autologous SCT. Lumbar puncture was performed, and evaluation of the cerebrospinal fluid was

negative for malignant cells and for infection, showing only protein level to be mildly elevated (48 mg/dl). This is a preview of subscription content, access via your institution ACCESS

OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Learn more Buy this article * Purchase on

SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about

institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Kharfan-Dabaja MA, Ayala E, Greene J, Rojiani A, Murtagh FR, Anasetti C . Two cases of progressive

multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature. _Bone Marrow Transplant_ 2007; 39: 101–107. Article  CAS  Google Scholar  *

Brickelmaier M, Lugovskoy A, Kartikeyan R, Reviriego-Mendoza MM, Allaire N, Simon K _et al_. Identification and characterization of mefloquine efficacy against JC virus _in vitro_.

_Antimicrob Agents Chemother_ 2009; 53: 1840–1849. Article  CAS  Google Scholar  * Koralnik IJ . New insights into progressive multifocal leukoencephalopathy. _Curr Opin Neurol_ 2004; 17:

365–370. Article  Google Scholar  * Carson KR, Evens AM, Richey EA, Habermann TM, Focosi D, Seymour JF _et al_. Progressive multifocal leukoencephalopathy after rituximab therapy in

HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. _Blood_ 2009; 113: 4834–4840. Article  CAS  Google Scholar  * Blick G, Whiteside M,

Griegor P, Hopkins U, Garton T, LaGravinese L . Successful resolution of progressive multifocal leukoencephalopathy after combination therapy with cidofovir and cytosine arabinoside. _Clin

Infect Dis_ 1998; 26: 191–192. Article  CAS  Google Scholar  * Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K _et al_. The human polyomavirus, JCV, uses serotonin receptors to

infect cells. _Science_ 2004; 306: 1380e3. Article  Google Scholar  * Rodriguez M, Lennon VA . Immunoglobulins promote remyelination in the central nervous system. _Ann Neurol_ 1990; 27:

12–17. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Istituto di Ematologia, Università Cattolica Sacro Cuore, Rome, Italy L Fianchi, M T

Voso, G Leone & L Pagano * Istituto di Radiologia, Università Cattolica Sacro Cuore, Rome, Italy C Colosimo * Istituto di Malattie Infettive, Università Cattolica Sacro Cuore, Rome,

Italy A De Luca * Dipartimento di Neurochirurgia, Università Cattolica Sacro Cuore, Rome, Italy A Pompucci * Istituto di Microbiologia, Università Cattolica Sacro Cuore, Rome, Italy P

Cattani * Istituto di Anatomia Patologica, Università Cattolica Sacro Cuore, Rome, Italy L M LaRocca Authors * L Fianchi View author publications You can also search for this author inPubMed

 Google Scholar * C Colosimo View author publications You can also search for this author inPubMed Google Scholar * A De Luca View author publications You can also search for this author

inPubMed Google Scholar * A Pompucci View author publications You can also search for this author inPubMed Google Scholar * P Cattani View author publications You can also search for this

author inPubMed Google Scholar * M T Voso View author publications You can also search for this author inPubMed Google Scholar * L M LaRocca View author publications You can also search for

this author inPubMed Google Scholar * G Leone View author publications You can also search for this author inPubMed Google Scholar * L Pagano View author publications You can also search for

this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to L Fianchi. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fianchi, L., Colosimo, C., De Luca, A. _et al._ Atypical presentation of progressive multifocal leukoencephalopathy

in a multiple myeloma patient after auto-SCT successfully treated with combination therapy. _Bone Marrow Transplant_ 45, 1668–1670 (2010). https://doi.org/10.1038/bmt.2010.33 Download

citation * Published: 01 March 2010 * Issue Date: November 2010 * DOI: https://doi.org/10.1038/bmt.2010.33 SHARE THIS ARTICLE Anyone you share the following link with will be able to read

this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative