Successful engraftment of a second transplant from unrelated cord blood identifying acceptable hla ag mismatches as treatment for primary graft failure possibly mediated by anti-hla abs after ‘mega-dose’ haploidentical pbsc transplantation

Access through your institution Buy or subscribe Patients with preformed Abs are at increased risk of rejection after solid organ transplantation;1 however, the function of Ab-mediated

rejection in hematopoietic SCT is still not completely understood. The use of sensitive solid-phase Ab detection assays, such as LABScreen (One Lambda, Canoga Park, CA, USA), which are based

on flow cytometry, has enhanced our ability to detect and identify donor-specific anti-HLA Abs (DSA). LABScreen Single Antigen (One Lambda) had single recombinant HLA class I and class II

Ag on each bead. This report describes a patient with anti-HLA Abs who achieved successful engraftment after HLA-mismatched cord blood transplantation (CBT) due to primary graft failure

after ‘mega-dose’ PBSC transplantation. Table 1 shows the anti-HLA Abs identified before treatment, and the HLA of the patient and the donors. We identify the epitopes with unique amino-acid

positions according to the epitope analysis that was reported by Maruya _et al._2 This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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Hospital, Maebashi, Gunma, Japan T Hoshino, T Sakura, K Miyawaki, N Hatsumi, S Takada & S Miyawaki * HLA Laboratory, NPO, Kyoto, Kyoto, Japan E Maruya & H Saji Authors * T Hoshino

View author publications You can also search for this author inPubMed Google Scholar * T Sakura View author publications You can also search for this author inPubMed Google Scholar * K

Miyawaki View author publications You can also search for this author inPubMed Google Scholar * N Hatsumi View author publications You can also search for this author inPubMed Google Scholar

* S Takada View author publications You can also search for this author inPubMed Google Scholar * E Maruya View author publications You can also search for this author inPubMed Google

Scholar * H Saji View author publications You can also search for this author inPubMed Google Scholar * S Miyawaki View author publications You can also search for this author inPubMed 

Google Scholar CORRESPONDING AUTHOR Correspondence to T Hoshino. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hoshino, T., Sakura, T., Miyawaki, K. _et al._ Successful engraftment of a second transplant from unrelated cord blood identifying acceptable

HLA Ag mismatches as treatment for primary graft failure possibly mediated by anti-HLA Abs after ‘mega-dose’ haploidentical PBSC transplantation. _Bone Marrow Transplant_ 45, 1665–1667

(2010). https://doi.org/10.1038/bmt.2010.30 Download citation * Published: 01 March 2010 * Issue Date: November 2010 * DOI: https://doi.org/10.1038/bmt.2010.30 SHARE THIS ARTICLE Anyone you

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