Kir genes and kir ligands affect occurrence of acute gvhd after unrelated, 12/12 hla matched, hematopoietic stem cell transplantation

ABSTRACT Interactions of polymorphic killer Ig-like receptor (KIR) receptors with KIR ligands have been shown to modify the outcome of hematopoietic SCT (HSCT). The association of these

genetic factors with different transplantation endpoints, however, varies substantially, depending on clinical and study setup variables. We aimed to assess whether KIR ligands, KIR genes

and KIR haplotypes are associated with HSCT outcome of 124 patients with various hematological malignancies, transplanted with 12/12 HLA matched grafts from unrelated donors. For this

purpose, patient and donor KIR gene and KIR ligand polymorphisms were determined and correlated with clinical data in simple and multiple models. We found that a missing HLA-C2 ligand for

donor inhibitory KIR2DL1 was significantly associated with an increased risk of acute GVHD (aGVHD) (II–IV) (hazard ratio (HR)=2.23, 95% confidence interval (95% CI): 1.21–4.10, _P_=0.010),

as were the AA KIR haplotypes in patients and donors in HLA-C1CX (HR=2.37, 95% CI: 1.16–4.84, _P_=0.018) and in HLA-Bw4− (HR=3.20, 95% CI: 1.35–7.60, _P_=0.008) patients. On the contrary,

transplantation of HLA-C1C2 patients with KIR2DS2 positive grafts were associated with a decreased risk of aGVHD (II–IV) (HR=0.24, 95% CI: 0.07–0.85, _P_=0.027). Thus, our single center

study provides evidence for the modification of aGVHD risk by KIRs and their ligands. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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(TRANSNET). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Blood Group Serology, Medical University of Vienna, Vienna, Austria K Ludajic, A Rosenmayr, I Fae & G F Fischer *

Department of Genetic Epidemiology, University of Goettingen, Goettingen, Germany, Y Balavarca & H Bickeböller * Department of Internal Medicine I, Bone Marrow Transplantation, Medical

University of Vienna, Vienna, Austria M Kouba, D Pohlreich, P Kalhs & H T Greinix Authors * K Ludajic View author publications You can also search for this author inPubMed Google Scholar

* Y Balavarca View author publications You can also search for this author inPubMed Google Scholar * H Bickeböller View author publications You can also search for this author inPubMed 

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inPubMed Google Scholar * G F Fischer View author publications You can also search for this author inPubMed Google Scholar * M Kouba View author publications You can also search for this

author inPubMed Google Scholar * D Pohlreich View author publications You can also search for this author inPubMed Google Scholar * P Kalhs View author publications You can also search for

this author inPubMed Google Scholar * H T Greinix View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to G F Fischer.

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ludajic, K., Balavarca, Y., Bickeböller, H. _et al._ KIR genes and KIR ligands affect occurrence of acute

GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation. _Bone Marrow Transplant_ 44, 97–103 (2009). https://doi.org/10.1038/bmt.2008.432 Download citation *

Received: 31 July 2008 * Revised: 28 November 2008 * Accepted: 02 December 2008 * Published: 26 January 2009 * Issue Date: July 2009 * DOI: https://doi.org/10.1038/bmt.2008.432 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * KIR receptors * KIR ligands * KIR haplotypes * acute GVHD