Monitoring of post-transplant remission of childhood malignancies: is there a standard?

ABSTRACT Chimerism analysis has become an important tool for the peri-transplant surveillance of engraftment. It offers the possibility to realize imminent graft rejection and it can serve

as an indicator for the recurrence of the underlying malignant or non-malignant disease. In addition to this analysis, the characterization of residual disease (MRD) prior to and in the

course of follow-up post transplant has become an important prognostic factor to highlight patients at highest risk for relapse. Consecutive post transplant MRD monitoring, together with

chimerism analysis, allows the detection of impending relapse in a substantial group of children transplanted for acute leukemia. Consequently, these investigations have become the basis for

treatment intervention, for example, to avoid graft rejection, to maintain engraftment and to treat imminent relapse by pre-emptive immunotherapy. Access through your institution Buy or

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INTENSIVE MONITORING OF MINIMAL RESIDUAL DISEASE AND CHIMERISM AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE LEUKEMIA IN CHILDREN Article 02 September 2021

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IMPACT OF HIGH-SENSITIVITY FLOW CYTOMETRY ON PERI-TRANSPLANT MINIMAL RESIDUAL DISEASE KINETICS IN ACUTE LEUKEMIA Article Open access 26 February 2025 REFERENCES * Kolb HJ, Mittermuller J,

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2: 150–156. CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by the ‘Wilhelm Sander Stiftung’, München, Germany and the ‘Deutsche Krebshilfe’, Bonn,

Germany [PB]. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University Children's Hospital, Clinic for Hematology/Oncology, Frankfurt, Germany P Bader, A Willasch & T Klingebiel

Authors * P Bader View author publications You can also search for this author inPubMed Google Scholar * A Willasch View author publications You can also search for this author inPubMed 

Google Scholar * T Klingebiel View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to P Bader. ADDITIONAL INFORMATION

CONFLICT OF INTEREST Peter Bader received lecture fees from an unnamed source. All other authors have declared no financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Bader, P., Willasch, A. & Klingebiel, T. Monitoring of post-transplant remission of childhood malignancies: is there a standard?. _Bone Marrow Transplant_

42 (Suppl 2), S31–S34 (2008). https://doi.org/10.1038/bmt.2008.280 Download citation * Published: 29 October 2008 * Issue Date: 01 October 2008 * DOI: https://doi.org/10.1038/bmt.2008.280

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * chimerism * MRD * acute leukemia * SCT * children and adolescence