C-erbb-3 protein expression in ovarian tumours

ABSTRACT In this study the expression of c-erbB-3 protein was investigated in a range of human ovarian tumours using a monoclonal antibody (RTJ1) raised to a synthetic peptide from the

cytoplasmic domain of the human c-erbB-3 protein. A total of 73 samples from 71 patients were graded as negative, weak, moderate or strong according to the intensity of immunohistochemical

staining observed, and this was related to tumour characteristics and other clinical parameters. In terms of positivity vs negativity, of the 73 samples examined, 62 (85%) showed positive

immunohistochemical staining for c-erbB-3. The majority of all ovarian tumours studied were positive for c-erbB-3 regardless of whether they were malignant (89%), borderline (100%) or benign

(61%), however the incidence of positivity was significantly less in the benign group than in overtly malignant tumours (P = 0.03). c-erbB-3 positivity was not significantly associated with

either age at diagnosis, tumour stage, differentiation, ploidy, percentage in S-phase or post-operative tumour bulk in malignant tumours. In terms of intensity of staining no significant

difference was observed either within the common epithelial group or between this group and tumours of a benign nature. A significantly more intense pattern of c-erbB-3 staining was observed

in tumours of borderline malignancy when compared with their overtly malignant counterparts (P = 0.002). Patients presenting with early-stage malignant tumours (I/II) were more likely to

display intense tumour staining than those with late-stage disease (III/IV) (P = 0.04). These investigations suggest that c-erbB-3 protein is frequently expressed in both benign and

malignant ovarian tumours, and that overexpression is more common in borderline and early invasive lesions. Access through your institution Buy or subscribe This is a preview of subscription

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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS INCREASED FOXJ1 PROTEIN EXPRESSION IS

ASSOCIATED WITH IMPROVED OVERALL SURVIVAL IN HIGH-GRADE SEROUS OVARIAN CARCINOMA: AN OVARIAN TUMOR TISSUE ANALYSIS CONSORTIUM STUDY Article Open access 02 November 2022 CLINICAL AND

PATHOLOGICAL ASSOCIATIONS OF PTEN EXPRESSION IN OVARIAN CANCER: A MULTICENTRE STUDY FROM THE OVARIAN TUMOUR TISSUE ANALYSIS CONSORTIUM Article Open access 18 June 2020 A COMPARATIVE STUDY OF

RTK GENE STATUS BETWEEN PRIMARY TUMORS, LYMPH-NODE METASTASES, AND KRUKENBERG TUMORS Article 30 July 2020 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * ICRF Medical Oncology Unit, Western

General Hospitals NHS Trust, Edinburgh, UK BJB Simpson Authors * BJB Simpson View author publications You can also search for this author inPubMed Google Scholar * J Weatherill View author

publications You can also search for this author inPubMed Google Scholar * EP Miller View author publications You can also search for this author inPubMed Google Scholar * AM Lessells View

author publications You can also search for this author inPubMed Google Scholar * SP Langdon View author publications You can also search for this author inPubMed Google Scholar * WR Miller

View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Simpson, B.,

Weatherill, J., Miller, E. _et al._ c-_erb_B-3 protein expression in ovarian tumours. _Br J Cancer_ 71, 758–762 (1995). https://doi.org/10.1038/bjc.1995.147 Download citation * Issue Date:

01 April 1995 * DOI: https://doi.org/10.1038/bjc.1995.147 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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