Inhibition of leukaemia cell proliferation by folic acid–polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into hl-60 cells

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Inhibition of leukaemia cell proliferation by folic acid–polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into hl-60 cells"


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ABSTRACT The inhibitory effect of c-myb antisense oligodeoxynucleotides (ODNs) conjugated to folic acid (FA) on HL-60 cell proliferation was examined. Folic acid was covalently linked to a


polylysine chain and purified by gel chromatography. Sterile FA-polylysine was complexed with c-myb sense and antisense. Exposure of HL-60 cells to the FA-polylysine-c-myb antisense ODN


complex resulted in a down-regulation of c-myb expression and a greater inhibition of proliferation than that obtained using free ODNs. Moreover, FA-polylysine conjugate alone or complexed


to c-myb sense ODN was not toxic to cells. The antigenic properties and uptake of the vitamin were not affected by the polylysine chain. These data suggest that this strategy is potentially


useful for the selective delivery of anti-oncogene-targeted ODNs into cancer cells. Access through your institution Buy or subscribe This is a preview of subscription content, access via


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MYELOID CELLS AND THEIR BONE MARROW PROGENITORS Article Open access 03 February 2025 NANO-FENRETINIDE DEMONSTRATES REMARKABLE ACTIVITY IN ACUTE PROMYELOID LEUKEMIA CELLS Article Open access


14 June 2024 THE CURRENT LANDSCAPE OF NUCLEIC ACID THERAPEUTICS Article 31 May 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Laboratorio Chemioterapia Sperimentale, Istituto Tumori


Regina Elena, Roma, Italy G Citro Authors * G Citro View author publications You can also search for this author inPubMed Google Scholar * C Szczylik View author publications You can also


search for this author inPubMed Google Scholar * P Ginobbi View author publications You can also search for this author inPubMed Google Scholar * G Zupi View author publications You can also


search for this author inPubMed Google Scholar * B Calabretta View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and


permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Citro, G., Szczylik, C., Ginobbi, P. _et al._ Inhibition of leukaemia cell proliferation by folic acid–polylysine-mediated introduction of


c-_myb_ antisense oligodeoxynucleotides into HL-60 cells. _Br J Cancer_ 69, 463–467 (1994). https://doi.org/10.1038/bjc.1994.84 Download citation * Issue Date: 01 March 1994 * DOI:


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