Epidermal growth factor and transforming growth factor α concentrations in bph and cancer of the prostate: their relationships with tissue androgen levels

ABSTRACT We measured immunoreactive EGF and TGF alpha in prostate tissue extracts obtained from 19 patients with benign prostatic hyperplasia (BPH) and 19 with cancer of the prostate (CaP).

Whilst both BPH and CaP expressed EGF (BPH = 195.61 +/- 19.94 ng g-1 protein; CaP = 235.60 +/- 24.45 ng g-1 protein) and TGF alpha (BPH = 92.57 +/- 7.60 ng g-1 protein; CaP = 100.73 +/-

15.47 ng g-1 protein) in equal concentrations, the levels of EGF in any tissue extract were on average twice those of TGF alpha. Furthermore analysis of the individual growth factor data

revealed a direct correlation between EGF and TGF alpha in both BPH (r = 0.72, P < 0.001) and CaP (r = 0.69, P < 0.001). When the tumours were classified according to their Gleason

score, a slight but significant increase in growth factor concentrations was noted as the tumour became less differentiated. We also measured the concentrations of testosterone and

dihydrotestosterone (DHT) in prostate extracts with a view of elucidating the relationship between androgen and growth factors in this gland. There was a small positive correlation only

between testosterone and EGF (r = 0.62, P < 0.05) and testosterone and TGF alpha (r = 0.61, P < 0.05) in CaP. The absence of any similar correlation in BPH where DHT becomes the

predominant hormone may suggest an indirect role for testosterone in the regulation of growth factor production. Access through your institution Buy or subscribe This is a preview of

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INFORMATION AUTHORS AND AFFILIATIONS * University Department of Surgery (WGH), Western General Hospital, Edinburgh, Scotland, UK Y Yang Authors * Y Yang View author publications You can also

search for this author inPubMed Google Scholar * GD Chisholm View author publications You can also search for this author inPubMed Google Scholar * FK Habib View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Yang, Y., Chisholm, G. & Habib, F. Epidermal

growth factor and transforming growth factor α concentrations in BPH and cancer of the prostate: their relationships with tissue androgen levels. _Br J Cancer_ 67, 152–155 (1993).

https://doi.org/10.1038/bjc.1993.26 Download citation * Issue Date: 01 January 1993 * DOI: https://doi.org/10.1038/bjc.1993.26 SHARE THIS ARTICLE Anyone you share the following link with

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