Prognostic significance of cathepsin-d in patients with breast cancer

ABSTRACT The expression of the protease cathepsin-D has been evaluated using an immunohistochemical technique with a polyclonal antibody in paraffin-embedded tissue from 359 patients treated

between the years 1975-1981 for Stage I and II breast cancer. One hundred and twenty seven patients (35%) have strongly positive, granular staining, 138 (38%) are intermediately stained in

the cytoplasm, and in 94 (26%) no staining is observed. There is a strong positive association between expression of cathepsin-D and the presence of tumour in axillary lymph nodes (P <

0.006). Expression of the protease is associated with significantly poorer survival of patients in univariate analysis (P = 0.025); however, this is not independent of other tumour

variables. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to

this journal Receive 24 print issues and online access $259.00 per year only $10.79 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy

now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact

customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NOVEL USES OF IMMUNOHISTOCHEMISTRY IN BREAST PATHOLOGY: INTERPRETATION AND PITFALLS Article 27 October 2020 PROTEOMIC ANALYSIS OF

ARCHIVAL BREAST CANCER CLINICAL SPECIMENS IDENTIFIES BIOLOGICAL SUBTYPES WITH DISTINCT SURVIVAL OUTCOMES Article Open access 16 February 2022 COMPARATIVE EVALUATION OF COLLAGEN MODIFICATIONS

IN BREAST CANCER IN HUMAN AND CANINE CARCINOMAS Article Open access 21 November 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Surgery, University of Liverpool Medical

School, UK JHR Winstanley Authors * JHR Winstanley View author publications You can also search for this author inPubMed Google Scholar * SJ Leinster View author publications You can also

search for this author inPubMed Google Scholar * TG Cooke View author publications You can also search for this author inPubMed Google Scholar * BR Westley View author publications You can

also search for this author inPubMed Google Scholar * AM Platt-Higgins View author publications You can also search for this author inPubMed Google Scholar * PS Rudland View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Winstanley, J., Leinster, S.,

Cooke, T. _et al._ Prognostic significance of cathepsin-D in patients with breast cancer. _Br J Cancer_ 67, 767–772 (1993). https://doi.org/10.1038/bjc.1993.139 Download citation * Issue

Date: 01 April 1993 * DOI: https://doi.org/10.1038/bjc.1993.139 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative