Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia

ABSTRACT The effects of progressive cachexia on protein metabolism in skeletal muscle has been investigated in mice bearing the MAC16 adenocarcinoma which produces cachexia with tumour

burdens of < 1% of the host weight. Weight loss was accompanied by loss of whole body nitrogen in proportion to the overall loss of body mass. Using L-[4-3H]phenylalanine to label

proteins in gastrocnemius muscle, a significant depression (60%) in protein synthesis occurred in animals with a weight loss between 15 and 30% accompanied by an increase in protein

degradation, which increased with increasing weight loss between 15 and 30%. Muscle degradation in vitro could be achieved by serum from cachectic animals, which appeared to contain a

proteolysis-inducing factor. These results suggest that the increased degradation of skeletal muscle seen in this model of cachexia may be due to a circulating proteolysis-inducing factor.

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MURF1 IMPEDES PANCREATIC TUMOR GROWTH Article Open access 13 May 2023 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Cancer Research Campaign Experimental Chemotherapy Group, Pharmaceutical

Sciences Institute, Aston University, Birmingham, UK KL Smith Authors * KL Smith View author publications You can also search for this author inPubMed Google Scholar * MJ Tisdale View author

publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Smith, K., Tisdale, M.

Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia. _Br J Cancer_ 67, 680–685 (1993). https://doi.org/10.1038/bjc.1993.126 Download

citation * Issue Date: 01 April 1993 * DOI: https://doi.org/10.1038/bjc.1993.126 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable

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