Hla class i gene expression on human primary tumours and autologous metastases: demonstration of selective losses of hla antigens on colorectal, gastric and laryngeal carcinomas

ABSTRACT The expression of HLA class I antigens was studied in 99 primary tumour (colorectal, gastric and laryngeal carcinomas) and 57 autologous metastases using immunohistological

techniques and monoclonal antibodies against class I monomorphic determinants, HLA-B isotypic determinants and HLA polymorphic determinants. Fourteen per cent of colorectal, 9.6% of gastric

and 20% of laryngeal carcinomas completely lacked class I molecules. Selective losses of HLA-B antigens were also detected in 8.8, 3.4 and 5.8% of these tumours respectively. Taking into

account complete and selective loss of HLA-B the average alteration in the class I molecules expression totalled 21%. The comparison of class I expression between primary tumours and

autologous metastases showed differences in 24% of the patients. These differences consisted mainly in a decrease of class I expression by metastases. Nevertheless, four types of divergence

were detected in laryngeal carcinomas, namely: +/-, +/+, -/+, -/-. In addition, a clear correlation between degree of differentiation and class I expression was observed in laryngeal

tumours. Finally, when class I gene RFLPs were compared with DNA from 15 tumours and autologous normal mucosa or peripheral lymphocytes, no differences were detected between these samples.

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May 2023 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Servicio de Análisis Clínicos, Hospital Virgen de las Nieves, Granada, Spain MA López-Nevot Authors * MA López-Nevot View

author publications You can also search for this author inPubMed Google Scholar * F Esteban View author publications You can also search for this author inPubMed Google Scholar * A Ferrón

View author publications You can also search for this author inPubMed Google Scholar * J Gutiérrez View author publications You can also search for this author inPubMed Google Scholar * MR

Oliva View author publications You can also search for this author inPubMed Google Scholar * C Romero View author publications You can also search for this author inPubMed Google Scholar * C

Huelin View author publications You can also search for this author inPubMed Google Scholar * F Ruiz-Cabello View author publications You can also search for this author inPubMed Google

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López-Nevot, M., Esteban, F., Ferrón, A. _et al._ HLA class I gene expression on human primary tumours and autologous metastases: demonstration of selective losses of HLA antigens on

colorectal, gastric and laryngeal carcinomas. _Br J Cancer_ 59, 221–226 (1989). https://doi.org/10.1038/bjc.1989.45 Download citation * Issue Date: 01 February 1989 * DOI:

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