Warfarin inhibits metastasis of mtln3 rat mammary carcinoma without affecting primary tumour growth

Nature

Warfarin inhibits metastasis of mtln3 rat mammary carcinoma without affecting primary tumour growth"


Play all audios:

Loading...

ABSTRACT Coumarin anticoagulants inhibit metastasis in several animal models, but the mechanism of this effect is uncertain. In order to determine the role of cytotoxic and/or cytostatic


actions of coumarins on the tumour cells, we have studied the effects of warfarin on tumour cell growth in a model in which tumour metastasis is inhibited by this drug. Clonogenic assay,


growth curve analysis and thymidine labelling index revealed that warfarin had no effects on Mtln3 mammary carcinoma cell growth in vitro at concentrations below 1 mM. The growth rate of


subcutaneously implanted Mtln3 tumour deposits in female F344 rats, assessed by weight and by stathmokinetic analysis of the tumour tissue, was identical in warfarin-treated and control


animals. Spontaneous metastasis from such tumours to the lungs was, however, significantly reduced in warfarin-treated animals (median 0 pulmonary tumours per animal in warfarin treated,


eight tumours per animal in control animals; P less than 0.05, Mann-Whitney). The mean plasma warfarin concentration in warfarin treated rats was 1.63 microM. These results suggest that


warfarin treatment of the host animal can inhibit tumour metastasis without having any direct or indirect effect on the growth rate of the tumour cells. Access through your institution Buy


or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 24 print issues and


online access $259.00 per year only $10.79 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes


which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY


OTHERS RANOLAZINE: A POTENTIAL ANTI-METASTATIC DRUG TARGETING VOLTAGE-GATED SODIUM CHANNELS Article Open access 29 February 2024 ANTITUMOR AND ANTIMETASTATIC EFFECTS OF DIETARY SULFORAPHANE


IN A TRIPLE-NEGATIVE BREAST CANCER MODELS Article Open access 11 July 2024 POTENTIAL EFFECT OF CHLOROQUINE AND PROPRANOLOL COMBINATION TO TREAT COLORECTAL AND TRIPLE-NEGATIVE BREAST CANCERS


Article Open access 16 May 2023 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University Department of Surgery, Western Infirmary, Glasgow, UK P McCulloch Authors * P McCulloch View author


publications You can also search for this author inPubMed Google Scholar * WD George View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND


PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McCulloch, P., George, W. Warfarin inhibits metastasis of Mtln3 rat mammary carcinoma without affecting primary


tumour growth. _Br J Cancer_ 59, 179–183 (1989). https://doi.org/10.1038/bjc.1989.37 Download citation * Issue Date: 01 February 1989 * DOI: https://doi.org/10.1038/bjc.1989.37 SHARE THIS


ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard


Provided by the Springer Nature SharedIt content-sharing initiative


Trending News

Unidirectional luminescence from ingan/gan quantum-well metasurfaces

ABSTRACT III–nitride light-emitting diodes (LEDs) are the backbone of ubiquitous lighting and display applications. Impa...

Jonny bairstow axed from england test squad for tour to new zealand

England have left out Jonny Bairstow from their 15-man squad for the two Tests against New Zealand, starting on November...

Javascript support required...

Deshotel bill would scrap testing as graduation requirement

Education leaders in the House and Senate each have competing plans to scale back Texas’ school testing requirements and...

What man utd icon ferguson was 'told' about cavani transfer

Manchester United have, after all these years, finally succeeded in signing Edinson Cavani. The Paris Saint-Germain icon...

Latests News

Warfarin inhibits metastasis of mtln3 rat mammary carcinoma without affecting primary tumour growth

ABSTRACT Coumarin anticoagulants inhibit metastasis in several animal models, but the mechanism of this effect is uncert...

A neural machine code and programming framework for the reservoir computer

ABSTRACT From logical reasoning to mental simulation, biological and artificial neural systems possess an incredible cap...

How lululemon got kicked in the (butt-baring) pants

Lululemon Athletica is having a tough week. The Vancouver-based maker of yoga-wear reported fourth-quarter results that ...

Decoding calcium signals involved in cardiac growth and function

ABSTRACT Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the am...

Existence is disputable | Nature Astronomy

Kepler-1625b-I and Kepler-1708b-I are the most noteworthy exomoon candidates to date. A new analysis of the available da...

Top