Warfarin inhibits metastasis of mtln3 rat mammary carcinoma without affecting primary tumour growth

Nature

Warfarin inhibits metastasis of mtln3 rat mammary carcinoma without affecting primary tumour growth"


Play all audios:

Loading...

ABSTRACT Coumarin anticoagulants inhibit metastasis in several animal models, but the mechanism of this effect is uncertain. In order to determine the role of cytotoxic and/or cytostatic


actions of coumarins on the tumour cells, we have studied the effects of warfarin on tumour cell growth in a model in which tumour metastasis is inhibited by this drug. Clonogenic assay,


growth curve analysis and thymidine labelling index revealed that warfarin had no effects on Mtln3 mammary carcinoma cell growth in vitro at concentrations below 1 mM. The growth rate of


subcutaneously implanted Mtln3 tumour deposits in female F344 rats, assessed by weight and by stathmokinetic analysis of the tumour tissue, was identical in warfarin-treated and control


animals. Spontaneous metastasis from such tumours to the lungs was, however, significantly reduced in warfarin-treated animals (median 0 pulmonary tumours per animal in warfarin treated,


eight tumours per animal in control animals; P less than 0.05, Mann-Whitney). The mean plasma warfarin concentration in warfarin treated rats was 1.63 microM. These results suggest that


warfarin treatment of the host animal can inhibit tumour metastasis without having any direct or indirect effect on the growth rate of the tumour cells. Access through your institution Buy


or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 24 print issues and


online access $259.00 per year only $10.79 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes


which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY


OTHERS RANOLAZINE: A POTENTIAL ANTI-METASTATIC DRUG TARGETING VOLTAGE-GATED SODIUM CHANNELS Article Open access 29 February 2024 ANTITUMOR AND ANTIMETASTATIC EFFECTS OF DIETARY SULFORAPHANE


IN A TRIPLE-NEGATIVE BREAST CANCER MODELS Article Open access 11 July 2024 POTENTIAL EFFECT OF CHLOROQUINE AND PROPRANOLOL COMBINATION TO TREAT COLORECTAL AND TRIPLE-NEGATIVE BREAST CANCERS


Article Open access 16 May 2023 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University Department of Surgery, Western Infirmary, Glasgow, UK P McCulloch Authors * P McCulloch View author


publications You can also search for this author inPubMed Google Scholar * WD George View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND


PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McCulloch, P., George, W. Warfarin inhibits metastasis of Mtln3 rat mammary carcinoma without affecting primary


tumour growth. _Br J Cancer_ 59, 179–183 (1989). https://doi.org/10.1038/bjc.1989.37 Download citation * Issue Date: 01 February 1989 * DOI: https://doi.org/10.1038/bjc.1989.37 SHARE THIS


ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard


Provided by the Springer Nature SharedIt content-sharing initiative


Trending News

Farmer focus: too much to ask for regular rainfall? - farmers weekly

© Jim Wileman The Christmas and New Year period carried on in much the same way as the second half of 2017, with rain be...

Page Not Found

Page Not Found The content that you're looking for is unavailable. You might find what you are looking for by using the ...

Banksafe training in action: teamwork at one ohio bank stops financial exploitation in its tracks

Memorial Day Sale! Join AARP for just $11 per year with a 5-year membership Join now and get a FREE gift. Expires 6/4  G...

Love: a simple word with profound meaning

LOVE: A SIMPLE WORD WITH PROFOUND MEANING _Sharing the gospel of Jesus Christ begins with love. When we love God and our...

Opinion: everything's wrong in california — and yes, progressives can fix it

Good morning. I’m Paul Thornton, and it is Saturday, Feb. 13, 2021. Let’s take a look back at the week in Opinion. I kno...

Latests News

Warfarin inhibits metastasis of mtln3 rat mammary carcinoma without affecting primary tumour growth

ABSTRACT Coumarin anticoagulants inhibit metastasis in several animal models, but the mechanism of this effect is uncert...

To what extent can the ozone valley over the tibetan plateau influence the east asian summer precipitation?

ABSTRACT The ozone valley over the Tibetan Plateau (OVTP) has experienced significant interannual variations during the ...

Thanks for visiting !

The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy.We ask that you ...

What is the inf treaty? Why is it causing chaos between us and russia?

President Donald Trump announced on October 22 he wants to pull American out of the Intermediate-Range Nuclear Forces Tr...

Billy joel ‘wasn’t surprised’ cbs abruptly moved out his special: ‘i’ve always kind of been cut short by tv’

Billy Joel may be a big shot everywhere — but, he says, not when it comes to TV. That’s what the 75-year-old Long Island...

Top