Bone mineral content of women receiving tamoxifen for mastalgia

ABSTRACT Dual photon absorptiometry (DPA) has been used to measure the effect of short and medium-term administration of tamoxifen on bone density in the axial skeleton of women with

mastalgia. This provided a unique opportunity to monitor the effect of this 'anti-oestrogenic' agent in predominantly premenopausal women, not suffering from malignancy. In

addition, plasma levels of calcium, phosphate, alkaline phosphatase and serum levels of oesteocalcin (GLA) have been assayed, both before and after 3 months of starting either tamoxifen or

placebo treatment. No significant alterations in bone density were seen. Osteocalcin, alkaline phosphatase and electrolytes were unchanged and there was no dose response observed in women

receiving either 10 mg or 20 mg of tamoxifen. Although possessing anti-oestrogenic properties, tamoxifen is also a partial agonist. Administration for the short periods does not measurably

influence spinal or femoral bone density and thus the agent can probably be given safely for the short-term treatment of mastalgia. Access through your institution Buy or subscribe This is a

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DENSITY IN WOMEN NEWLY DIAGNOSED WITH BREAST CANCER: A PROSPECTIVE COHORT STUDY Article Open access 17 February 2022 STEROID HORMONE LEVELS AND BONE MINERAL DENSITY IN WOMEN OVER 65 YEARS OF

AGE Article Open access 25 March 2023 BONE HEALTH IN NEWLY DIAGNOSED FEMALE BREAST CANCER PATIENTS IN CHINA: A CROSS-SECTIONAL STUDY Article Open access 01 February 2025 AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Department of Clinical Oncology, Guy's Hospital, London, UK IS Fentiman Authors * IS Fentiman View author publications You can also search for this author

inPubMed Google Scholar * M Caleffi View author publications You can also search for this author inPubMed Google Scholar * A Rodin View author publications You can also search for this

author inPubMed Google Scholar * B Murby View author publications You can also search for this author inPubMed Google Scholar * I Fogelman View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fentiman, I., Caleffi, M., Rodin, A. _et al._ Bone mineral content of

women receiving tamoxifen for mastalgia. _Br J Cancer_ 60, 262–264 (1989). https://doi.org/10.1038/bjc.1989.266 Download citation * Issue Date: 01 August 1989 * DOI:

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