Effects of cyclic-nucleotide derivatives on the growth of human colonic carcinoma xenografts and on cell production in the rat colonic crypt epithelium

ABSTRACT Previous studies have shown that various amine hormones are able to influence the growth rate of human colorectal carcinomas propagated as xenografts in immune-deprived mice, and it

is now well known that the effects of many amine and other hormones are mediated by cyclic nucleotides, acting as second messengers within cells. In the present study the influence of

various derivatives of cyclic adenosine monophosphate and cyclic guanosine monophosphate on the growth of two different lines of colorectal cancer growing in immune-deprived mice, and on the

cell production rate in the colonic crypt epithelium of the rat, was assessed. Growth of each tumour line, as well as crypt-cell production, was suppressed by treatment wit N6O2'

dibutyryl and N6 monobutyryl derivatives of cyclic adenosine monophosphate. Dibutyryl cyclic guanosine monophosphate, on the other hand, was found to promote the growth of Tumour HXK4 and to

promote crypt cell production, but to have no significant effect on Tumour HXM2. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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NUCLEOSIDES EXCRETION IN PATIENTS WITH METASTATIC COLORECTAL CANCER Article Open access 14 December 2021 THE ROLE OF POLYAMINES IN GASTRIC CANCER Article 09 June 2021 ROLE OF ADENOMATOUS

POLYPOSIS COLI IN PROLIFERATION AND DIFFERENTIATION OF COLON EPITHELIAL CELLS IN ORGANOID CULTURE Article Open access 17 February 2021 Authors * P J Tutton View author publications You can

also search for this author inPubMed Google Scholar * D H Barkla View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tutton, P., Barkla, D. Effects of cyclic-nucleotide derivatives on the growth of human colonic carcinoma xenografts and on cell production in

the rat colonic crypt epithelium. _Br J Cancer_ 44, 182–188 (1981). https://doi.org/10.1038/bjc.1981.169 Download citation * Issue Date: 01 August 1981 * DOI:

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