Early responses to chemotherapy detected by pulse cytophotometry

ABSTRACT DNA/cell distributions were recorded by automated cytofluorometry (=pulse cytophotometry) in bone-marrow aspirates of leukaemia and lymphosarcoma patients subjected to chemotherapy.

In most cases, early perturbations in DNA/cell histographs were observed, characteristically reflecting the known mode of action of the drugs. These changes in general preceded the clinical

observation of drug response. In a series of 23 measurements in 19 patients, a positive correlation between early cytophotometric changes and clinical effects of chemotherapy was observed

in 17 patients. Five patients were negative for both cytophotometric and clinical reactions and one patient was probably false-positive. The validity of the assay for early detection of drug

resistance in acute leukaemia and related diseases is discussed. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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DETECTION BY MULTIPARAMETRIC FLOW CYTOMETRY IN ACUTE MYELOID LEUKEMIA Article Open access 18 July 2022 ULTRA-SENSITIVE MONITORING OF LEUKEMIA PATIENTS USING SUPERRCA MUTATION DETECTION

ASSAYS Article Open access 12 July 2022 Authors * L A Smets View author publications You can also search for this author inPubMed Google Scholar * E Mulder View author publications You can

also search for this author inPubMed Google Scholar * F C de Waal View author publications You can also search for this author inPubMed Google Scholar * F J Cleton View author publications

You can also search for this author inPubMed Google Scholar * J Blok View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Smets, L., Mulder, E., de Waal, F. _et al._ Early responses to chemotherapy detected by pulse cytophotometry. _Br J Cancer_ 34, 153–161

(1976). https://doi.org/10.1038/bjc.1976.137 Download citation * Issue Date: 01 August 1976 * DOI: https://doi.org/10.1038/bjc.1976.137 SHARE THIS ARTICLE Anyone you share the following link

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