Transcription and epigenetics | Nature

Access through your institution Buy or subscribe Transcriptional programs drive cell identity, dictating the specialized phenotypes of differentiated cells during the development of

multicellular organisms. Interplay between signal-transduction pathways, transcription factors and the chromatin packaging of the genome sets the gene expression pattern of a cell, which

must be relatively stably maintained once an organism is fully developed. The Reviews in this Insight explore how transcriptional states are regulated during development and disease. The

discovery that differentiated cells can be artificially reprogrammed into induced pluripotent stem cells by a small set of transcription factors has opened up exciting medical prospects and

provided an opportunity to investigate how stable epigenetic states are built and reversed. Effie Apostolou and Konrad Hochedlinger discuss transcriptional and chromatin-based mechanisms

behind cellular reprogramming and draw comparisons with tumorigenesis. This is a preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing

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AFFILIATIONS * Senior Editors, Alex Eccleston, Francesca Cesari & Magdalena Skipper Authors * Alex Eccleston View author publications You can also search for this author inPubMed Google

Scholar * Francesca Cesari View author publications You can also search for this author inPubMed Google Scholar * Magdalena Skipper View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Eccleston, A., Cesari, F. & Skipper, M. Transcription and epigenetics.

_Nature_ 502, 461 (2013). https://doi.org/10.1038/502461a Download citation * Published: 23 October 2013 * Issue Date: 24 October 2013 * DOI: https://doi.org/10.1038/502461a SHARE THIS

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