The association between body size, prostate volume and prostate-specific antigen
The association between body size, prostate volume and prostate-specific antigen"
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
ABSTRACT Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume,
prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from
the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent
among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume. Access
through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal
Receive 4 print issues and online access $259.00 per year only $64.75 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may
be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support
SIMILAR CONTENT BEING VIEWED BY OTHERS RELATIONSHIP BETWEEN SERUM TOTAL TESTOSTERONE AND PROSTATE VOLUME IN AGING MEN Article Open access 08 July 2021 THE USE OF PROSTATE SPECIFIC ANTIGEN
DENSITY TO PREDICT CLINICALLY SIGNIFICANT PROSTATE CANCER Article Open access 17 November 2020 CLINICAL UTILITY OF A SERUM BIOMARKER PANEL IN DISTINGUISHING PROSTATE CANCER FROM BENIGN
PROSTATE HYPERPLASIA Article Open access 23 July 2021 REFERENCES * Isaacs JT, Coffey DS . Etiology and disease process of benign prostatic hyperplasia. _Prostate_ 1989; 2: 33–50. Article
CAS Google Scholar * Flegal KM, Carroll MD, Ogden CL, Johnson CL . Prevalence and trends in obesity among US adults, 1999–2000. _J Am Med Assoc_ 2002; 288: 1723–1727. Article Google
Scholar * Wannamethee SG, Shaper AG, Morris RW, Whincup PH . Measures of adiposity in the identification of metabolic abnormalities in elderly men. _Am J Clin Nutr_ 2005; 81: 1313–1321.
Article CAS Google Scholar * Dahle SE, Chokkalingam AP, Gao YT, Deng J, Stanczyk FZ, Hsing AW . Body size and serum levels of insulin and leptin in relation to the risk of benign
prostatic hyperplasia. _J Urol_ 2002; 168: 599–604. Article CAS Google Scholar * Zucchetto A, Tavani A, Dal Maso L, Gallus S, Negri E, Talamini R _et al_. History of weight and obesity
through life and risk of benign prostatic hyperplasia. _Int J Obesity_ 2005; 29: 798–803. Article CAS Google Scholar * Hammarsten J, Hogstedt B, Holthuis N, Mellstrom D . Components of
the metabolic syndrome – risk factors for the development of benign prostatic hyperplasia. _Prostate Cancer Prostatic Dis_ 1998; 1: 157–162. Article CAS Google Scholar * Soygur T, Kupeli
B, Aydos K, Kupeli S, Arikan N, Muftuoglu YZ . Effect of obesity on prostatic hyperplasia: its relation to sex steroid levels. _Int Urol Nephrol_ 1996; 28: 55–59. Article CAS Google
Scholar * Sarma AV, Jaffe CA, Schottenfeld D, Dunn R, Montie JE, Cooney KA _et al_. Insulin-like growth factor-1, insulin-like growth factor binding protein-3, and body mass index: clinical
correlates of prostate volume among Black men. _Urology_ 2002; 59: 362–367. Article Google Scholar * Freedland SJ, Platz EA, Presti Jr JC, Aronson WJ, Amling CL, Kane CJ _et al_. Obesity,
serum prostate specific antigen and prostate size: implications for prostate cancer detection. _J Urol_ 2006; 175: 500–504. Article Google Scholar * Parsons JK, Carter HB, Partin AW,
Windham BG, Metter EJ, Ferrucci L _et al_. Metabolic factors associated with benign prostatic hyperplasia. _J Clin Endocrinol Metab_ 2006; 91: 2562–2568. Article CAS Google Scholar *
Schuurman AG, Goldbohm RA, Dorant E, van den Brandt PA . Anthropometry in relation to prostate cancer risk in the Netherlands Cohort Study. _Am J Epidemiol_ 2000; 151: 541–549. Article CAS
Google Scholar * Presti JC, Lee U, Brooks JD, Terris MK . Lower body mass index is associated with a higher prostate cancer detection rate and less favorable pathological features in a
biopsy population. _J Urol_ 2004; 171: 2199–2202. Article Google Scholar * Kulkarni GS, Al-Azab R, Lockwood G, Toi A, Evans A, Trachtenberg J _et al_. Evidence for a biopsy derived grade
artifact among larger prostate glands. _J Urol_ 2006; 175: 505–509. Article Google Scholar * Fontaine KR, Heo M, Allison DB . Obesity and prostate cancer screening in the USA. _Public
Health_ 2005; 119: 694–698. Article CAS Google Scholar * Fowke JH, Signorello LB, Underwood W, Ukoli FA, Blot WJ . Obesity and prostate cancer screening among African–American and
Caucasian men. _Prostate_ 2006; 66: 1371–1380. Article Google Scholar * Baillargeon J, Pollock BH, Kristal AR, Bradshaw P, Hernandex J, Basler J _et al_. The association of body mass index
and prostate-specific antigen in a population-based study. _Cancer_ 2005; 103: 10920–11095. Google Scholar * Kristal AR, Chi C, Tangen C, Goodman PJ, Etzioni R, Thompson IM . Associations
of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase. _Cancer_ 2005; 106: 320–328. Article Google Scholar * Farnsworth
WE . Estrogen in the etiophathogenesis of BPH. _Prostate_ 1999; 41: 263–274. Article CAS Google Scholar * Coffey DS . Similarities of prostate and breast cancer: evolution, diet, and
estrogens. _Urology_ 2001; 57: 31–38. Article CAS Google Scholar * Bray I, Gunnell D, Holly JM, Middleton N, Smith GD, Martin RM . Associations of childhood and adulthood height and the
components of height with insulin-like growth factor (IGF) levels in adulthood: 65 year follow-up of the Boyd Orr cohort. _J Clin Endocrinol Metab_ 2006; 91: 1382–1389. Article CAS Google
Scholar * Rhodes T, Girman CJ, Jacobsen SJ, Roberts RO, Guess HA, Lieber MM . Longitudinal prostate growth rates during 5 years in randomly selected community men 40–79 years old. _J Urol_
1999; 161: 1174–1179. Article CAS Google Scholar * Calle EE . Invited commentary: do anthropometric measures predict risk of prostate cancer? _Am J Epidemiol_ 2000; 151: 550–553. Article
CAS Google Scholar * Fowke JH, Signorello LB, Chang SS, Matthews CE, Buchowski MS, Cookson MS _et al_. Effects of obesity and height on PSA and percent free PSA levels among
African–American and Caucasian men. _Cancer_ 2006; 107: 2361–2367. Article CAS Google Scholar * Werny DM, Saraiya S, Blackman D . Prostate-specific antigen levels in diabetics and
non-diabetics from the National Health and Nutrition Examination Survey, 2001–2002. _Fourth Annual AACR Frontiers in Cancer Prevention Conference_. * Kaaks R, Lukanova A, Rinaldi S, Biessy
C, Soderberg S, Olsson T _et al_. Interrelationships between plasma testosterone, SHBG, IGF-I, insulin and leptin in prostate cancer cases and controls. _Eur J Cancer Prev_ 2003; 12:
309–315. Article CAS Google Scholar * Sakr WA, Grignon DJ, Crissman JD, Heilbrun LK, Cassin BJ, POntes JJE _et al_. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic
adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. _In Vivo_ 1994; 8: 439–444. CAS Google Scholar * Ogden CL, Fryar C, Carroll MD, Flegal KM . _Mean body weight,
height, and body mass index, United States 1960–2002_. Advance Data from Vital and Health Statistics: National Center for Health Statistics, vol. 347, 2004, pp 1–20. * Freedland SJ, Isaacs
WB, Platz EA, Terris MK, Aronson WJ, Amling CL _et al_. Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search
database study. _J Clin Oncol_ 2005; 23: 7546–7554. Article Google Scholar Download references ACKNOWLEDGEMENTS Funding was provided by the NIH CA98348, DAMD17-02-1-0139 and M01 RR00095 to
the Vanderbilt General Clinical Research Center. We are grateful to Dr C Eckstein and the clinical and nursing staff at the Urology Associates, the Veterans Administration and Vanderbilt,
for essential collaboration on this project. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Internal Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt
University Medical Center, Nashville, TN, USA J H Fowke & S S Motley * Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA M S Cookson, R Concepcion,
S S Chang & J A Smith Jr * Urology Associates, Nashville, TN, USA R Concepcion * Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA M L Wills Authors * J
H Fowke View author publications You can also search for this author inPubMed Google Scholar * S S Motley View author publications You can also search for this author inPubMed Google Scholar
* M S Cookson View author publications You can also search for this author inPubMed Google Scholar * R Concepcion View author publications You can also search for this author inPubMed
Google Scholar * S S Chang View author publications You can also search for this author inPubMed Google Scholar * M L Wills View author publications You can also search for this author
inPubMed Google Scholar * J A Smith Jr View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to J H Fowke. ADDITIONAL
INFORMATION CONFLICT OF INTEREST The authors state no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fowke, J., Motley, S.,
Cookson, M. _et al._ The association between body size, prostate volume and prostate-specific antigen. _Prostate Cancer Prostatic Dis_ 10, 137–142 (2007).
https://doi.org/10.1038/sj.pcan.4500924 Download citation * Received: 18 August 2006 * Revised: 03 October 2006 * Accepted: 09 October 2006 * Published: 19 December 2006 * Issue Date: 01 May
2007 * DOI: https://doi.org/10.1038/sj.pcan.4500924 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link
is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * obesity * prostate volume * height * PSA *
benign prostatic hyperplasia
Trending News
What we’ve learnt from building africa’s biggest genome libraryThe human genome was first sequenced in 2003 by multiple research centres across the world. The breakthrough was hailed ...
At an average of 1,200 passengers per day, maya train numbers far from eventual targetWill the Maya Train railroad eventually become a popular mode of travel between beach resorts, colonial cities and archa...
Shelter home abuse case: cbi starts excavation of burial ground; suspect grave of victim girlsThe CBI has started excavation of a grave in Bihar's Muzzafarpur, where, it is suspected, remains of some of the vi...
High stakes get build-to-rent star claire solon going at greystarA business trip to London about 10 years ago gave Claire Solon a glimpse of a future that she believes will fail. At the...
Targeted modulation of immune cells and tissues using engineered biomaterialsABSTRACT Therapies modulating the immune system offer the prospect of treating a wide range of conditions including infe...
Latests News
The association between body size, prostate volume and prostate-specific antigenABSTRACT Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We ...
Pirates of the caribbean 6: disney confirm johnny depp is outBack in October the screenwriter of Pirates of the Caribbean: The Curse of The Black Pearl – the first film in the franc...
5 tips for budget-friendly travel in los cabosIn recent years, Los Cabos has repositioned itself as a luxury destination, a process helped by a slew of newly opened p...
Nature geoscience - volume 1 issue 8, august 2008Cratons are ancient continental nuclei that have resisted significant fragmentation for almost two billion years. Yet, m...
Quintana roo opens investigation into possible drugging of 2 us college studentsThe Quintana Roo Attorney General’s Office (FGE) said Friday that it has opened an investigation into the alleged druggi...