The association between body size, prostate volume and prostate-specific antigen

ABSTRACT Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume,

prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from

the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent

among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume. Access

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the Vanderbilt General Clinical Research Center. We are grateful to Dr C Eckstein and the clinical and nursing staff at the Urology Associates, the Veterans Administration and Vanderbilt,

for essential collaboration on this project. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Internal Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt

University Medical Center, Nashville, TN, USA J H Fowke & S S Motley * Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA M S Cookson, R Concepcion,

 S S Chang & J A Smith Jr * Urology Associates, Nashville, TN, USA R Concepcion * Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA M L Wills Authors * J

H Fowke View author publications You can also search for this author inPubMed Google Scholar * S S Motley View author publications You can also search for this author inPubMed Google Scholar

* M S Cookson View author publications You can also search for this author inPubMed Google Scholar * R Concepcion View author publications You can also search for this author inPubMed 

Google Scholar * S S Chang View author publications You can also search for this author inPubMed Google Scholar * M L Wills View author publications You can also search for this author

inPubMed Google Scholar * J A Smith Jr View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to J H Fowke. ADDITIONAL

INFORMATION CONFLICT OF INTEREST The authors state no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fowke, J., Motley, S.,

Cookson, M. _et al._ The association between body size, prostate volume and prostate-specific antigen. _Prostate Cancer Prostatic Dis_ 10, 137–142 (2007).

https://doi.org/10.1038/sj.pcan.4500924 Download citation * Received: 18 August 2006 * Revised: 03 October 2006 * Accepted: 09 October 2006 * Published: 19 December 2006 * Issue Date: 01 May

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is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * obesity * prostate volume * height * PSA *

benign prostatic hyperplasia