Characterization of the fgf axis and identification of a novel fgfr1iiic isoform during prostate cancer progression in the tramp model

ABSTRACT Expression of the fibroblast growth factor (FGF) axis was examined during prostate cancer progression in the autochthonous _Tr_ansgenic _A_denocarcinoma of _M_ouse _P_rostate

(TRAMP) model, including TRAMP derived cell lines. Transcripts for FGF-7 and FGF-10 that are normally expressed by the stroma were detected in all samples, including the epithelial cell

lines, suggesting that elaboration of these factors by the epithelium may be an essential event during transformation. Interestingly FGFR2iiib, the FGF-7 and FGF-10 receptor, was

downregulated during tumor progression whereas a novel FGFR1iiic (Φ) inframe splice form was found to be expressed. These observations support the hypothesis that specific changes in FGF

axis correlate with, and probably facilitate, tumor progression. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ABERRANT ANDROGEN ACTION IN PROSTATIC PROGENITOR CELLS INDUCES ONCOGENESIS

AND TUMOR DEVELOPMENT THROUGH IGF1 AND WNT AXES Article Open access 28 July 2022 APPEARANCE OF TUFT CELLS DURING PROSTATE CANCER PROGRESSION Article Open access 29 June 2023 TRIM28 PROMOTES

LUMINAL CELL PLASTICITY IN A MOUSE MODEL OF PROSTATE CANCER Article 08 March 2023 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Cell Biology, Baylor College of Medicine,

Houston, USA BA Foster, PJ Kaplan & NM Greenberg * Scott Department of Urology, Baylor College of Medicine, Houston, USA NM Greenberg Authors * BA Foster View author publications You can

also search for this author inPubMed Google Scholar * PJ Kaplan View author publications You can also search for this author inPubMed Google Scholar * NM Greenberg View author publications

You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Foster, B., Kaplan, P. & Greenberg, N.

Characterization of the FGF axis and identification of a novel FGFR1iiic isoform during prostate cancer progression in the TRAMP model. _Prostate Cancer Prostatic Dis_ 2, 76–82 (1999).

https://doi.org/10.1038/sj.pcan.4500297 Download citation * Received: 04 December 1998 * Revised: 03 February 1999 * Accepted: 04 February 1999 * Published: 21 May 1999 * Issue Date: 01

March 1999 * DOI: https://doi.org/10.1038/sj.pcan.4500297 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * prostate cancer * TRAMP * fibroblast

growth factor * androgen receptor * stromal-epithelial interaction