Gabaergic dysfunction in mood disorders

ABSTRACT The authors review the available literature on the preclinical and clinical studies involving GABAergic neurotransmission in mood disorders. γ-Aminobutyric acid (GABA) is an

inhibitory neurotransmitter present almost exclusively in the central nervous system (CNS), distributed across almost all brain regions, and expressed in interneurons modulating local

circuits. The role of GABAergic _dysfunction_ in mood disorders was first proposed 20 years ago. Preclinical studies have suggested that GABA levels may be decreased in animal models of

depression, and clinical studies reported low plasma and CSF GABA levels in mood disorder patients. Also, antidepressants, mood stabilizers, electroconvulsive therapy, and GABA agonists have

been shown to reverse the depression-like behavior in animal models and to be effective in unipolar and bipolar patients by increasing brain GABAergic activity. The hypothesis of reduced

GABAergic activity in mood disorders may complement the monoaminergic and serotonergic theories, proposing that the balance between multiple neurotransmitter systems may be altered in these

disorders. However, low GABAergic cortical function may probably be a feature of a subset of mood disorder patients, representing a genetic susceptibility. In this paper, we discuss the

status of GABAergic hypothesis of mood disorders and suggest possible directions for future preclinical and clinical research in this area. Access through your institution Buy or subscribe

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PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS This work was partly supported by the National Institute of Mental Health (MH 01736), NARSAD, and the Veterans Administration. Dr

Brambilla was supported by grants from the University of Pavia and from the Fatebenefratelli-Brescia (Ministry of Health). We thank A Mangiò ([email protected]) for great help with the

figure. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Biological Psychiatry Unit, IRCCS S Giovanni di Dio, Fatebenefratelli, Brescia, Italy P Brambilla & J Perez * Department of

Psychiatry, IRCCS S Matteo, University of Pavia, Italy F Barale * Advanced Biotechnology Center, University of Genova, Italy G Schettini * Department of Psychiatry, The University of Texas

Health Sciences Center, San Antonio, TX, USA J C Soares * Audie Murphy Division, South Texas VA Health Care System, San Antonio, TX, USA J C Soares Authors * P Brambilla View author

publications You can also search for this author inPubMed Google Scholar * J Perez View author publications You can also search for this author inPubMed Google Scholar * F Barale View author

publications You can also search for this author inPubMed Google Scholar * G Schettini View author publications You can also search for this author inPubMed Google Scholar * J C Soares View

author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to P Brambilla. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Brambilla, P., Perez, J., Barale, F. _et al._ GABAergic dysfunction in mood disorders. _Mol Psychiatry_ 8, 721–737 (2003).

https://doi.org/10.1038/sj.mp.4001362 Download citation * Received: 09 January 2003 * Revised: 11 April 2003 * Accepted: 16 April 2003 * Published: 30 July 2003 * Issue Date: 01 August 2003

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * GABA * bipolar disorder * unipolar disorder * mood

disorders * antidepressants * mood stabilizers