Regulation of transcription by proteins that control the cell cycle
Regulation of transcription by proteins that control the cell cycle"
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ABSTRACT In eukaryotes, progression of a cell through the cell cycle is partly controlled at the level of transcriptional regulation. Yeast and mammalian cells use similar mechanisms to
achieve this regulation. Although gaps still remain, progress has been made recently in connecting the links between the cell's cycle and its transcriptional machinery. Access through
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BEING VIEWED BY OTHERS SINGLE GENE ANALYSIS IN YEAST SUGGESTS NONEQUILIBRIUM REGULATORY DYNAMICS FOR TRANSCRIPTION Article Open access 23 July 2024 TRANSCRIPTIONAL CONDENSATES: A BLESSING OR
A CURSE FOR GENE REGULATION? Article Open access 16 February 2024 EMERGING INSIGHTS INTO TRANSCRIPTIONAL CONDENSATES Article Open access 25 April 2024 REFERENCES * Weinberg, R. A. The
retinoblastoma protein and cell cycle control. _Cell_ 81, 323–330 (1995). Article CAS Google Scholar * Huang, H. J. _et al_. Supression of the neoplastic phenotype by replacement of the
_RB_ gene in human cancer cells. _Science_ 242, 1563–1566 (1988). Article ADS CAS Google Scholar * Goodrich, D. W., Wang, N. P., Qian, Y.-W., Lee, E. Y.-H. P. & Lee, W.-H. The
retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. _Cell_ 67, 293–302 (1991). Article CAS Google Scholar * Hinds, P. W. _et al_. Regulation of
retinoblastoma protein functions by ectopic expression of human cyclins. _Cells_ 70, 993–1006 (1992). Article CAS Google Scholar * Connell-Crowley, L., Harper, J. W. & Goodrich, D. W.
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. _Mol. Biol. Cell_ 8, 287–301 (1997). Article CAS Google Scholar * Dyson, N.
pRB, p107, and the regulation of the E2F transcription factor. _J. Cell Sci. (suppl.)_ 18, 81–87 (1994). Article CAS Google Scholar * Hiebert, S. W., Chellappan, S. P., Horowitz, J. M.
& Nevins, J. R. The interaction of pRb with E2F inhibits the transcriptional activity of E2F. _Genes Dev._ 6, 177–185 (1992). Article CAS Google Scholar * Helin, K., Harlow, E. &
Fattaey, A. R. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. _Mol. Cell Biol._ 13, 6501–6508 (1993). Article CAS Google Scholar * Dynlacht, B. D.,
Flores, O., Lees, J. A. & Harlow, E. Differential regulation of E2F _trans_-activation by cyclin-cdk2 complexes. _Genes Dev._ 8, 1772–1786 (1994). Article CAS Google Scholar *
Weintraub, S. J. _et al_. Retinoblastoma protein switches the E2F site from positive to negative element. _Nature_ 375, 812–815 (1995). Article ADS CAS Google Scholar * Zwicker, J., Liu,
N., Engeland, K., Lucibello, F. & Muller, R. Cell cycle regulation of E2F site occupation _in vivo_. _Science_ 271, 1595–1597 (1996). Article ADS CAS Google Scholar * Johnson, D.
G., Ohtani, K. & Nevins, J. R. Autoregulatory control of E2F-1 expression in response to positive and negative regulators of cell cycle progression. _Genes Dev._ 8, 1514–1525 (1994).
Article CAS Google Scholar * Yamasaki, L. _et al_. Tumor induction and tissue atrophy in mice lacking E2F-1. _Cell_ 85, 537–548 (1996). Article CAS Google Scholar * Field, S. _et al_.
E2F-1 functions in mice to promote apoptosis and suppress proliferation. _Cell_ 85, 549–561 (1996). Article CAS Google Scholar * Singh, P., Coe, J. & Hong, W. Arole for retinoblastoma
protein in potentiating transcriptional activation by the glucocorticoid receptor. _Nature_ 374, 562–565 (1995). Article ADS CAS Google Scholar * Sánchez, I. & Dynlacht, B.
Transcriptional control fo the cell cycle. _Curr. Opin. Cell Biol._ 8, 318–324 (1996). Article Google Scholar * Cavanaugh, A. H. _et al_. Activity of RNA polymerase I transcription factor
UBF blocked by Rb gene product. _Nature_ 374, 177–180 (1995). Article ADS CAS Google Scholar * White, R., Trouche, D., Martin, K., Jackson, S. & Kouzarides, T. Repression of RNA
polymerase III transcription by the retinoblastoma protein. _Nature_ 382, 88–90 (1996). Article ADS CAS Google Scholar * Zhu, L. _et al_. Inhibition of cell proliferation by p107, a
relative of the retinoblastoma protein. _Genes Dev._ 7, 1111–1125 (1993). Article CAS Google Scholar * Zamanian, M. & Thangue, N. B. L. Transcriptional repression by the Rb-related
protein p107. _Mol. Biol. Cell_ 4, 389–396 (1993). Article CAS Google Scholar * Vairo, G., Livingston, D. M. & Ginsberg, D. Functional interaction between E2F-4 and p130: Evidence for
distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. _Genes Dev._ 9, 869–881 (1995). Article CAS Google Scholar * Lee, M.-H. _et al_.
Targeted disruption of _p107_: functional overlap between _p107_ and _Rb_. _Genes Dev._ 10, 1621–1632 (1996). Article CAS Google Scholar * Cobrinik, D. _et al_. Shared role of the
pRB-related p130 and p107 proteins in limb development. _Genes Dev._ 10, 1633–1644 (1996). Article CAS Google Scholar * Zhu, L., Harlow, E. & Dynlacht, B. D. p107 uses a
p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. _Genes Dev._ 9, 1740–1752 (1995). Article CAS Google Scholar * Woo, M. S.-A., Sanchez, I. & Dynlacht, B.
D. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. _Mol. Cell. Biol._ 17, 3566–3579 (1997). Article CAS Google Scholar * Mudryj, M. _et al_.
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. _Cell_ 65, 1243–1253 (1991). Article CAS Google Scholar * Krek, W. _et al_. Negative
regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. _Cell_ 78, 161–172 (1994). Article CAS Google Scholar * Dynlacht, B. D.,
Moberg, K., Lees, J. A., Harlow, E. & Zhu, L. Specific regulation of E2F family members by cyclin-dependent kinases. _Mol. Cell. Biol._ 17, 3867–3875 (1997). Article CAS Google
Scholar * Prives, C. & Manfredi, J. J. The p53 tumor suppressor protein. _Genes Dev._ 7, 529–534 (1993). Article CAS Google Scholar * Wang, Y. & Prives, C. Increased and altered
DNA binding of p53 by S and G2/M but not G1 cyclin-dependent kinases. _Nature_ 376, 88–91 (1995). Article ADS CAS Google Scholar * Bischoff, J. R., Friedman, P. N., Marshak, D. R.,
Prives, C. & Beach, D. Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. _Proc. Natl Acad. Sci. USA_ 87, 4766–4770 (1990). Article ADS CAS Google Scholar * Sturzbecher,
H.-W. _et al_. p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis. _Oncogene_ 5, 795–801 (1990). CAS PubMed Google Scholar * Koch, C. &
Nasmyth, K. Cell cycle regulated transcription in yeast. _Curr. Opin. Cell Biol._ 6, 451–459 (1994). Article CAS Google Scholar * McIntosh, E. M. MCB elements and the regulation of DNA
replicaiton in yeast. _Curr. Genet._ 24, 185–192 (1993). Article CAS Google Scholar * Amon, A., Tyers, M., Futcher, B. & Nasmyth, K. Mechanisms that help the yeast cell cycle clock
tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. _Cell_ 74, 993–1007 (1993). Article CAS Google Scholar * Koch, C., Schleiffer, S., Ammerer, G. &
Nasmyth, K. Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace
it from the promoter in G2. _Genes Dev._ 10, 129–141 (1996). Article CAS Google Scholar * Conaway, R. C. & Conaway, J. W. An RNA polymerase II transcription factor has an associated
DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promoters. _Proc. Natl Acad. Sci. USA_ 86, 7356–7360 (1989). Article ADS CAS Google Scholar * Feaver, W.
J., Gileadi, O., Li, Y. & Kornberg, R. D. CTD kinase associated with yeast RNA polymerase II initiation factor b. _Cell_ 67, 1223–1230 (1991). Article CAS Google Scholar * Serizawa,
H., Conaway, R. C. & Conaway, J. W. Multifunctional RNA polymerase II initiation factor d from rat liver: relationship between carboxy-terminal kinase ATPase and DNA helicase activities.
_J. Biol. Chem._ 268, 17300–17308 (1993). CAS PubMed Google Scholar * Lu, H., Zawel, L., Fisher, L., Egly, J.-M. & Reinberg, D. Human general transcription factor IIH phosphorylates
the C-terminal domain of RNA polymerase II. _Nature_ 358, 641–645 (1992). Article ADS CAS Google Scholar * Sancar, A. Mechanisms of DNA excision repair. _Science_ 266, 1954–1956 (1994).
Article ADS CAS Google Scholar * Nigg, E. A. Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control? _Curr. Opin. Cell Biol._ 8, 312–317
(1996). Article CAS Google Scholar * Fisher, R. P. & Morgan, D. O. Anovel cyclin associates with MO15/cdk7 to form the cdk-activating kinase. _Cell_ 78, 713–724 (1994). Article CAS
Google Scholar * Makela, T. P. _et al_. Acyclin associated with the CDK-activating kinase MO15. _Nature_ 371, 254–257 (1994). Article ADS CAS Google Scholar * Roy, R. _et al_. The MO15
cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. _Cell_ 79, 1093–1101 (1994). Article CAS Google Scholar * Shiekhattar, R. _et al_. CDK-activating kinase
complex is a component of human transcription factor. _Nature_ 374, 283–287 (1995). Article ADS CAS Google Scholar * Serizawa, H. _et al_. Association of CDK-activating kinase subunits
with transcription factor TFIIH. _Nature_ 374, 280–282 (1995). Article ADS CAS Google Scholar * Cismowski, M. J., Laff, G. M., Solomon, M. J. & Reed, S. I. KIN28 encodes a C-terminal
domain kinase that controls mRNA transcription in _Saccharomyces cerevisiae_ but lacks cyclin-dependent kinase activating (CAK) activity. _Mol. Cell. Biol._ 15, 2983–2992 (1995). Article
CAS Google Scholar * Feaver, W. J., Svejstrup, J. Q., Henry, N. L. & Kornberg, R. D. Relationship of CDK-activating kinase and RNA polymerase II TD kinase TFIIH/TFIIK. _Cell_ 79,
1103–1109 (1994). Article CAS Google Scholar * Espinoza, F. H., Farrell, A., Erdjument-Bromage, H., Tempst, P. & Morgan, D. O. Acyclin-dependent kinase-activating kinase (CAK) in
budding yeast unrelated to vertebrate AK. _Science_ 273, 1714–1717 (1996). Article ADS CAS Google Scholar * Thuret, J. Y., Valay, J. G., Faye, G. & Mann, C. Civ1 (CAK _in vivo_), a
novel Cdk-activating kinase. _Cell_ 86, 565–576 (1996). Article CAS Google Scholar * Kaldis, P., Sutton, A. & Solomon, M. J. The Cdk-activating kinase (CAK) from budding yeast. _Cell_
86, 553–564 (1996). Article CAS Google Scholar * Makela, T. P. _et al_. Akinase-deficient transcription factor TFIIH is functional in basal and activated transcription. _Proc. Natl Acad.
Sci. USA_ 92, 5174–5178 (1995). Article ADS CAS Google Scholar * Akoulitchev, S., Makela, T. P., Weinberg, R. A. & Reinberg, D. Requirement for TFIIH kinase activity in
transcription by RNA polymerase II. _Nature_ 377, 557–560 (1995). Article ADS CAS Google Scholar * Yankulov, K. Y. & Bentley, D. L. Regulation of CDK7 substrate specificity by MAT1
and TFIIH. _EMBO J._ 16, 1638–1646 (1997). Article CAS Google Scholar * Rossignol, M., Kolb-Cheynel, I. & Egly, J.-M. Substrate specificity of the cdk-activating kinase (CAK) is
altered upon association with TFIIH. _EMBO J._ 16, 1628–1637 (1997). Article CAS Google Scholar * Liao, S.-M. _et al_. Akinase–cyclin pair in the RNA polymerase II holoenzyme. _Nature_
374, 193–196 (1995). Article ADS CAS Google Scholar * Kuchin, S., Yeghiayan, P. & Carlson, M. Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to
transcriptional control in yeast. _Proc. Natl Acad. Sci. USA_ 92, 4006–4010 (1995). Article ADS CAS Google Scholar * Rickert, P., Seghezzi, W., Shanahan, F., Cho, H. & Lees, E.
Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. _Oncogene_ 12, 2631–2640 (1996). CAS PubMed Google Scholar * Tassan, J.-P., Jaquenoud, M., Leopold, P., Schultz, S.
J. & Nigg, E. A. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. _Proc. Natl Acad. Sci. USA_ 92, 8871–8875 (1995). Article ADS CAS
Google Scholar * Maldonado, E. _et al_. Ahuman RNA polymerase II complex associated with SRB and DNA-repair proteins. _Nature_ 381, 86–89 (1996). Article ADS CAS Google Scholar *
Léopold, P. & O'Farrell, P. H. An evolutionarily conserved cyclin homolog from _Drosophila_ rescues yeast deficient in G1 cyclins. _Cell_ 66, 1207–1216 (1991). Article Google
Scholar * Lew, D. J., Dulic, V. & Reed, S. I. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) fucntion in yeast. _Cell_ 66, 1197–1206 (1991). Article CAS Google
Scholar * Gottesfeld, J. M., Wolf, V. J., Dang, T., Forbes, D. J. & Hartl, P. Mitotic repression of RNA polymerase III transcription _in vitro_ mediated by phosphorylation of a TFIIIB
component. _Science_ 263, 81–84 (1994). Article ADS CAS Google Scholar * Segil, N., Guermah, M., Hoffmann, A., Roeder, R. G. & Heintz, N. Mitotic regulation of TFIID: inhibition of
activator-dependent transcription and changes in subcellular localization. _Genes Dev._ 10, 2389–2400 (1996). Article CAS Google Scholar * Martinez-Balbas, M., Dey, A., Rabindran, S.,
Ozato, K. & Wu, C. Displacement of sequence-specific transcription factors from mitotic chromatin. _Cell_ 83, 29–38 (1995). Article CAS Google Scholar * Colgan, D. F., Murthy, K. G.
K., Prives, C. & Manley, J. Cell-cycle-related regulation of poly(A) polymerase by phsophorylation. _Nature_ 384, 282–285 (1996). Article ADS CAS Google Scholar * Moll, T., Tebb, G.,
Surana, U., Robitsch, H. & Nasmyth, K. The role of phosphorylation and the CD28 protein kinase in cell cycle-regulated nuclear import of the _S. cerevisiae_ transcription factor SWI5.
_Cell_ 66, 743–758 (1991). Article CAS Google Scholar * Lane, S., Farlie, P. & Watson, R. B-Myb function can be markedly enhanced by cyclin A-dependent kinase and protein truncation.
_Oncogene_ 14, 2445–2453 (1997). Article CAS Google Scholar * Hara, E., Hall, M. & Peters, G. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription
factors. _EMBO J._ 16, 332–342 (1997). Article CAS Google Scholar Download references ACKNOWLEDGEMENTS I thank E. Harlow, R. Erikson and I Sanchez for suggestions on this review. AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * the Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, 02138, Massachusetts, USA Brian D. Dynlacht
Authors * Brian D. Dynlacht View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS
ARTICLE Dynlacht, B. Regulation of transcription by proteins that control the cell cycle. _Nature_ 389, 149–152 (1997). https://doi.org/10.1038/38225 Download citation * Issue Date: 11
September 1997 * DOI: https://doi.org/10.1038/38225 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link
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