Research Highlights | Nature Reviews Genetics
Research Highlights | Nature Reviews Genetics"
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
You have full access to this article via your institution. Download PDF EVOLUTION EVOLUTIONARY EST ANALYSIS IDENTIFIES RAPIDLY EVOLVING MALE REPRODUCTIVE PROTEINS IN _DROSOPHILA_. Swanson,
W. J. _et al_. _Proc. Natl Acad. Sci. USA_ 98, 7375–7379 (2001) [PubMed] Reproductive proteins are likely candidates for causing the rapid divergence between closely related species, as
their modification favours adaptive divergence. To test this hypothesis, Swanson _et al_. compared the sequences of 285 ESTs (expressed sequence tags) isolated from the male accessory glands
— which secrete seminal-fluid proteins — of _Drosophila simulans_ and _D. melanogaster_. 11% of the 176 genes identified showed evidence of positive selection, and the 57 newly identified
accessory gland genes should become candidate genes for further positive selection studies. CANCER GENETICS MITOTIC RECOMBINATION EFFECTS HOMOZYGOSITY FOR _NF1_ GERMLINE MUTATIONS IN
NEUROFIBROMAS. Serra, E. _et al_. _Nature Genet._ 28, 294–296 (2001) [PubMed] Neurofibromatosis type 1 (NF1) is an autosomal-dominant disorder caused by mutations in the _NF1_ tumour
suppressor gene. Of the many cell types seen in NF1 nerve-sheath tumours, only Schwann cells are homozygous for _NF1_ mutations. Through molecular and _in situ_ hybridization of cultured
Schwann cells, this paper shows that loss of heterozygosity for _NF1_ occurs by mitotic recombination. As there is inter-individual variability in mitotic recombination rates, genes that
control this phenomenon might act as modifier genes for susceptibility to NF1 and other cancers. HUMAN GENETICS CHARCOT–MARIE–TOOTH DISEASE TYPE 2A CAUSED BY MUTATION IN A MICROTUBULE MOTOR
K1F1BΒ. Zhao, C. _et al_. _Cell_ 105, 587–597 (2001). [PubMed] CMT2A is a dominant subtype of Charcot–Marie–Tooth disease (CMT) — the most commonly inherited human peripheral neuropathy —
that maps to 1p35–36. When Zhao _et al_. knocked out the mouse β isoform of _K1f1B_ — which encodes a motor protein belonging to the kinesin superfamily — null mutants died at birth with
multiple neurological abnormalities, and heterozygotes developed progressive muscle weakness and defective synaptic vesicle transport. This CMT-like phenotype and the chromosome-1 map
location of _K1f1B_ lead the authors to analyse the gene in CMT2A patients, in whom they found loss-of-function mutations in the motor domain of _K1F1B_. As axons lack protein-synthesis
machinery, their survival depends on the transport of essential proteins. Haploinsufficiency for _K1f1B_ might therefore reduce levels of synaptic vesicle transport of essential factors and
receptors, leading to the impairment of nerve endings and to the decreased survival of peripheral neurons. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS
ARTICLE Research Highlights. _Nat Rev Genet_ 2, 566 (2001). https://doi.org/10.1038/35084571 Download citation * Issue Date: August 2001 * DOI: https://doi.org/10.1038/35084571 SHARE THIS
ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard
Provided by the Springer Nature SharedIt content-sharing initiative
Trending News
'ice stupa' sculpts artificial glaciers to ensure fresh water supply in rural indiait’s a well known fact that due to global warming, glaciers are melting and causing sea levels to rise. YET ONE ENGINEER...
Off the menu special: new year's eve dining in newport beach - newport beach newsBY CHRISTOPHER TRELA AND CATHERINE DEL CASALE | NB INDY What are you doing New Year’s Eve? We have a few suggestions cou...
'i loved making it' carol vorderman gushes as fans praise her flying eThe 54-year-old TV star took to the social media site to thank fans for their support after the show went out last night...
Is your computer secretly mining bitcoin alternatives? A guide to ‘cryptojacking’Nothing comes for free, especially online. Websites and apps that don’t charge you for their services are often collecti...
The bards of wales: a hungarian ballad | thearticleFranz Joseph I, the Habsburg Emperor who was also King of Hungary, sent in his army to defeat the Hungarian uprising aga...
Latests News
Research Highlights | Nature Reviews GeneticsYou have full access to this article via your institution. Download PDF EVOLUTION EVOLUTIONARY EST ANALYSIS IDENTIFIES R...
Faint galaxies light up the dark web filling the cosmosThe ‘cosmic web’ of gas spanning much of the Universe is illuminated by the faint glow of galaxies billions of parsecs a...
Camilla and charles beaming as royals visit bbcPRINCE CHARLES REVEALS DETAILS OF LAST CONVERSATION WITH FATHER The future King and Queen Consort were met by a group of...
How wildlife criminals are being caught by their own mobile phone dataIt was a typical day for Nikorn Wongprajan, who was manning the office of the Department of National Parks Plant and Ani...
Tyson fury retains heavyweight title with brutal ko of dillian whyte - and then hints at retirementGareth A Davies Boxing Correspondent, At Wembley Stadium. David Cosgrove Live Updates 23 April 2022 11:58pm BST * FURY D...