A map of fear | Nature Reviews Genetics
A map of fear | Nature Reviews Genetics"
- Select a language for the TTS:
- UK English Female
- UK English Male
- US English Female
- US English Male
- Australian Female
- Australian Male
- Language selected: (auto detect) - EN
Play all audios:
Mott et al. report a solution to the twofold problem of stock homogeneity and the need for a finer QTL mapping resolution. Their improved technique is illustrated by mapping five QTL for
emotionality in mice.
The classical way of mapping QTL involves crossing two inbred lines that differ in the mean phenotype of a given trait. Repeated intercrosses or backcrosses onto one parental strain are then
conducted to single out the regions with the QTL from the rest of the genome. To increase the resolution in QTL mapping, Mott et al. abandoned simple crosses between inbred lines in their
mapping studies in favour of a genetically heterogeneous stock, which was established 30 years ago from eight inbred founder strains. The highly recombinant nature of the heterogeneous stock
genome (which is a fine genetic mosaic of its founders) gives a 30-fold increase in the resolution for QTL mapping, allowing mapping of QTL to under 0.5 cM with fewer than 2,000 animals.
Because the heterogeneous stock was derived from eight different lines, it is also genetically diverse.
Anyone you share the following link with will be able to read this content:
Trending News
Blackmailer demanded £7,000 from victim over benefits claim 'leak'A woman who demanded £7,000 from her victim has walked free from court after being told by a judge she did a "stupi...
Mum's legal fight to keep 'gentle' pup Charlie after she was mis-sold XL BullyNewsMum's legal fight to keep 'gentle' pup Charlie after she was mis-sold XL BullyKaylie Staniland is fighting a legal b...
Teesside youngster living beauty pageant dream after reaching semi final of national contestNewsTeesside youngster living beauty pageant dream after reaching semi final of national contestTen-year-old Jazlyn Dsa ...
'I can't argue with that': Brazen burglar caught with YSL handbag full of jewellery THANKS judgeNews'I can't argue with that': Brazen burglar caught with YSL handbag full of jewellery THANKS judgeMichael Connors said...
Grandad's 'heartfelt' 55-mile charity walk for dementia in memory of beloved wifeNewsGrandad's 'heartfelt' 55-mile charity walk for dementia in memory of beloved wifeDr John Hirst raises £1,910 complet...
Latests News
A map of fear | Nature Reviews GeneticsMott et al. report a solution to the twofold problem of stock homogeneity and the need for a finer QTL mapping resolutio...
Shanghai reports 12 new COVID deaths as frustrations boil overSHANGHAI (Reuters) – The major financial hub of Shanghai reported 12 new COVID-19 related deaths on April 22, up from 11...
Replace the battery in your Nike+ receiver on the cheapGot one of them newfangled Nike+ setups? Doubtless you’re wondering what happens when the battery dies on the receiver. ...
Martin Lewis urges 'four checks' for anyone paying Council Tax as UK households could be owed thousands - Manchester Evening NewsMartin Lewis urges 'four checks' for anyone paying Council Tax as UK households could be owed thousandsThere are four re...
Redefining the lie: politics and porkiesRussell Marks has in the past received funding from the Australian Research Council and La Trobe University for a doctor...