Initiation of neural induction by fgf signalling before gastrulation

ABSTRACT During neural induction, the ‘organizer’ of the vertebrate embryo instructs neighbouring ectodermal cells to become nervous system rather than epidermis. This process is generally

thought to occur around the mid-gastrula stage of embryogenesis1. Here we report the isolation of _ ERNI_, an early response gene to signals from the organizer (Hensen's node). Using

_ERNI_ as a marker, we present evidence that neural induction begins before gastrulation—much earlier in development than previously thought. We show that the organizer and some of its

precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction. Access through your institution Buy or subscribe This is a preview of

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CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We thank A. Rosenthal and W. Ye (Genentech) for the FGFR1-IgG construct; R. Lovell-Badge for _Sox3_ and _Sox2_ and T. Jessell for

S17; C. Dulac for advice on the differential screen; B. Cigich for technical assistance; I. Skromne for Fig. 4b, c; C. Ang for zebrafinch tissue; and T. Jessell, G. Sheng, K. Storey and D.

Vasiliauskas for helpful comments on the manuscript. Supported by the National Institute of Mental Health. AUTHOR INFORMATION Author notes * Claudio D. Stern: Correspondence and requests for

materials should be addressed to C.D.S. AUTHORS AND AFFILIATIONS * Department of Genetics and Development, Andrea Streit, Costis Papanayotou, Andrés Sirulnik & Claudio D. Stern * Center

for Neurobiology and Behavior, Columbia University, 701 West 168th Street #1602, New York, 10032, New York, USA Alyson J. Berliner & Claudio D. Stern Authors * Andrea Streit View author

publications You can also search for this author inPubMed Google Scholar * Alyson J. Berliner View author publications You can also search for this author inPubMed Google Scholar * Costis

Papanayotou View author publications You can also search for this author inPubMed Google Scholar * Andrés Sirulnik View author publications You can also search for this author inPubMed 

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THIS ARTICLE Streit, A., Berliner, A., Papanayotou, C. _et al._ Initiation of neural induction by FGF signalling before gastrulation . _Nature_ 406, 74–78 (2000).

https://doi.org/10.1038/35017617 Download citation * Received: 14 March 2000 * Accepted: 03 May 2000 * Issue Date: 06 July 2000 * DOI: https://doi.org/10.1038/35017617 SHARE THIS ARTICLE

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