Adenosine mediates a slow hyperpolarizing synaptic potential in autonomic neurones

ABSTRACT Considerable evidence has accumulated suggesting that purines, adenosine and ATP function as neurotransmitters in the central and peripheral nervous systems1–4. Burnstock2 has

proposed that purinergic receptors be classified into two types, P1 and P2, having adenosine and ATP, respectively, as agonist prototypes. Recent data suggest that ATP may mediate a synaptic

potential in guinea pig vas deferons5,6, but no such evidence exists for adenosine. The presence of a non-cholinergic, non-adrenergic nerve supply to the urinary bladder has been

postulated7,8 and termed purinergic1,2, as these nerves have been shown to release ATP7. Furthermore, atropine-resistant contractions of bladder smooth muscle are thought to be mediated by

ATP, while _in situ_ experiments9,10 in vesical parasympathetic ganglia have suggested that a purinergic modulatory mechanism may control urinary bladder function. We now report the presence

of a slow hyperpolarizing synaptic potential (slow-h.s.p.) in neurones of cat vesical parasympathetic ganglia, produced by stimulating the preganglionic nerves, and provide evidence that

the slow-h.s.p. is mediated by adenosine. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

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subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS LC-DERIVED EXCITATORY SYNAPTIC TRANSMISSION TO DORSAL RAPHE SEROTONIN NEURONS IS INHIBITED BY

ACTIVATION OF ALPHA2-ADRENERGIC RECEPTORS Article 17 February 2024 MELATONIN INHIBITS MUSCULAR-MUCOSAL STRETCH-SENSITIVE BLADDER AFFERENTS VIA THE MT2 RECEPTORS Article Open access 21

October 2022 GHRELIN SIGNALING IN THE CEREBELLAR CORTEX ENHANCES GABAERGIC TRANSMISSION ONTO PURKINJE CELLS Article Open access 07 February 2023 REFERENCES * Burnstock, G. _J. Physiol.

Lond._ 313, 1–35 (1981). Article  CAS  Google Scholar  * Burnstock, G. _Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach_ (eds Smith, R. W. & Bolis, L.)

107–118 (Raven, New York, 1978). Google Scholar  * Stone, T. W. _Neuroscience_ 6, 523–555 (1981). Article  CAS  Google Scholar  * Phillis, J. W. & Wu, P. H. _Prog. Neurobiol._ 16,

187–239 (1981). Article  CAS  Google Scholar  * Sneddon, P. and Westfall, D. P. & Fedan, J. S. _Science_ 218, 693–695 (1982). Article  ADS  CAS  Google Scholar  * Sneddon, P. &

Westfall, D. P. _J. Physiol., Lond._ 347, 561–580 (1984). Article  CAS  Google Scholar  * Burnstock, G., Cocks, T., Kasakov, L. & Wong, H. K. _Eur. J. Pharmac._ 49, 145–149 (1978).

Article  CAS  Google Scholar  * Burnstock, G., Cocks, T., Crowe, R. & Kasakov, L. _Br. J. Pharmac._ 63, 125–138 (1978). Article  CAS  Google Scholar  * DeGroat, W. C. & Booth, A. M.

_Fedn. Proc._ 39, 2990–2996 (1980). CAS  Google Scholar  * DeGroat, W. C., Booth, A. M. & Krier, J. in _Integrative Functions of the Autonomic Nervous Systems_ (eds Brooks, C. M.,

Koizumi, K. & Sato, A.) 234–247 (University of Tokyo Press, 1979). Google Scholar  * Gallagher, J. P., Griffith, W. H. & Shinnick-Gallagher, P. _J. Physiol., Lond._ 332, 473–486

(1982). Article  CAS  Google Scholar  * Nimit, Y., Skolnick, P. & Daly, J. W. _J. Neurochem._ 36, 908–912 (1981). Article  CAS  Google Scholar  * Hartzell, N. C. _J. Physiol., Lond._

293, 23–50 (1979). Article  CAS  Google Scholar  * Henon, B. K. & McAfee, D. A. _J. Physiol., Lond._ 336, 607–620 (1983). Article  CAS  Google Scholar  * Ginsborg, B. L., House, C. R.

& Silinsky, E. M. _J. Physiol., Lond._ 236, 723–731 (1974). Article  CAS  Google Scholar  * Tomita, T. & Wantanabe, H. _J. Physiol., Lond._ 231, 167–178 (1973). Article  CAS  Google

Scholar  * Lotan, I., Dascal, N., Cohen, S. & Lass, Y. _Nature_ 298, 572–574 (1982). Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *

Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas, 77550, USA T. Akasu, P. Shinnick-Gallagher & J. P. Gallagher Authors * T. Akasu View

author publications You can also search for this author inPubMed Google Scholar * P. Shinnick-Gallagher View author publications You can also search for this author inPubMed Google Scholar *

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Akasu, T., Shinnick-Gallagher, P. & Gallagher, J. Adenosine mediates a slow hyperpolarizing synaptic potential in autonomic neurones. _Nature_ 311, 62–65 (1984).

https://doi.org/10.1038/311062a0 Download citation * Received: 15 May 1984 * Accepted: 20 June 1984 * Issue Date: 06 September 1984 * DOI: https://doi.org/10.1038/311062a0 SHARE THIS ARTICLE

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