Effect of plant cytokinins on microfilaments and tight junction permeability

ABSTRACT IN epithelia classified as “leaky”, net transport efficiency of NaCl and water may be determined not only by cellular metabolic activity, but also by tight junction permeability and

the conjugate physical driving forces acting between lumen and intercellular space. The significance of paracellular ion movement across leaky epithelia would become more apparent if a

cytoplasmic mechanism for regulation of tight junctional permeability could be defined. The structure–function observations reported here suggest that the microfilament system may have such

a function. Rapid and reversible increases in shunt path electrical resistance were observed in _Necturus_ gallbladder exposed to plant cytokinins. In electron micrographs zeiotic

transformation of the luminal membrane was associated with disruption of microfilaments and in freeze fracture, with reorientation and disorder of tight junctional elements. Access through

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BEING VIEWED BY OTHERS TIGHT JUNCTION CHANNEL REGULATION BY INTERCLAUDIN INTERFERENCE Article Open access 30 June 2022 NANOSCALE SEGREGATION OF CHANNEL AND BARRIER CLAUDINS ENABLES

PARACELLULAR ION FLUX Article Open access 25 August 2022 CLAUDIN-23 RESHAPES EPITHELIAL TIGHT JUNCTION ARCHITECTURE TO REGULATE BARRIER FUNCTION Article Open access 05 October 2023

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Moleculaire du CNRS et de l' Universite Paris VII, C. J. BENTZEL, B. HAINAU, A. EDELMAN, T. ANAGNOSTOPOULOS & E. L. BENEDETTI * Hôpital des Enfants Malades, Paris, France C. J.

BENTZEL, B. HAINAU, A. EDELMAN, T. ANAGNOSTOPOULOS & E. L. BENEDETTI Authors * C. J. BENTZEL View author publications You can also search for this author inPubMed Google Scholar * B.

HAINAU View author publications You can also search for this author inPubMed Google Scholar * A. EDELMAN View author publications You can also search for this author inPubMed Google Scholar

* T. ANAGNOSTOPOULOS View author publications You can also search for this author inPubMed Google Scholar * E. L. BENEDETTI View author publications You can also search for this author

inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BENTZEL, C., HAINAU, B., EDELMAN, A. _et al._ Effect of plant cytokinins on

microfilaments and tight junction permeability. _Nature_ 264, 666–668 (1976). https://doi.org/10.1038/264666a0 Download citation * Received: 19 July 1976 * Accepted: 12 October 1976 * Issue

Date: 16 December 1976 * DOI: https://doi.org/10.1038/264666a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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