Cancer, autoimmunity and iga-deficiency related by a common antigen–antibody system

ABSTRACT WORKERS1–5 have reported IgG-precipitating antibodies against predominantly high molecular weight ruminant immunoglobulins to be present in the sera of certain patients with IgA

deficiencies. The most frequently identified antigen is bovine IgM but we have also found a high frequency of precipitating antibodies to bovine associated mucoprotein (BAMP) (Table 1).

Immunochemical studies have demonstrated that the antibodies to these two proteins are entirely distinct and that antibodies to BAMP in human sera can only precipitate with a fraction of the

antigenic determinants detected by antisera raised in rabbits against BAMP. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TUMOR-ASSOCIATED AUTOANTIBODIES FROM MOUSE BREAST CANCER MODELS

ARE FOUND IN SERUM OF BREAST CANCER PATIENTS Article Open access 11 May 2021 AUTOIMMUNE GASTRITIS Article 09 July 2020 UNIQUE REPERTOIRE OF ANTI-CARBOHYDRATE ANTIBODIES IN INDIVIDUAL HUMAN

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AFFILIATIONS * Departments of Microbiology and Pathology, The University of Iowa College of Medicine, Iowa City, Iowa, 52240 JOHN E. BUTLER & RODGER OSKVIG Authors * JOHN E. BUTLER View

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AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE BUTLER, J., OSKVIG, R. Cancer, autoimmunity and IgA-deficiency related by a common antigen–antibody system.

_Nature_ 249, 830–833 (1974). https://doi.org/10.1038/249830a0 Download citation * Received: 30 January 1974 * Revised: 04 April 1974 * Issue Date: 28 June 1974 * DOI:

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