Augmentation of lymphocyte reactivity in guinea pigs, mice, monkeys and humans sensitised to bcg, dinitrochlorobenzene or nitrogen mustard

ABSTRACT NONSPECIFIC augmentation of tumour immunity has been achieved through the use of Bacillus Calmette-Guérin (BCG), _Corynebacterium parvum, Toxoplasma gondii, Besnoitia jellisoni_ and

other intracellular parasites1–4. Nonliving preparations, such as cell walls from BCG, also cause nonspecific augmentation of tumour immunity5. The mechanisms underlying these effects are

not clear. It has been postulated that amplification of macrophage or reticuloendothelial function is responsible for the enhancement of tumour immunity by these agents. In the mouse, BCG

causes a change in the rate of activation of macrophages, as well as a change in their lysosomal content and bacteriolytic power6,7. In the guinea pig, there is an initial granulomatous

reaction at the BCG inoculation site, followed by a peripheral histocyte-mediated destruction of tumour cells8. We have now examined the effect of intradermal BCG on the ‘specific’ and

‘nonspecific’ responsiveness of circulating lymphocytes. We also investigated the ability of two chemical agents to produce similar or additive effects. Access through your institution Buy

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OTHERS DIFFERENCES IN SKIN TEST REACTIONS TO OFFICIAL AND DEFINED ANTIGENS IN GUINEA PIGS EXPOSED TO NON-TUBERCULOUS AND TUBERCULOUS BACTERIA Article Open access 20 February 2023 HUMORAL

IMMUNE RESPONSE AND DELAYED-TYPE HYPERSENSITIVITY IN RABBITS INFECTED WITH _TRYPANOSOMA EQUIPERDUM_ Article Open access 10 September 2020 DIRECT ADMINISTRATION OF HUMAN LEUCOCYTE ANTIGEN

(DHLA) MOLECULES INTO TUMOUR SITES: PROPOSAL FOR A NEW IMMUNOTHERAPY FOR CANCER Article Open access 23 October 2023 REFERENCES * Mathé, G., _et al._, _Lancet_, I, 697 (1969). Article  Google

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Branch, National Cancer Institute, Bethesda, Maryland, 20014 MAX H. COHEN, PAUL B. CHRETIEN, EDWARD L. FELIX, BETTY C. LOYD & ALFRED S. KETCHAM * Surgical Neurology Branch, National

Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, 20014 LELAND A. ALBRIGHT & AYUB K. OMMAYA Authors * MAX H. COHEN View author

publications You can also search for this author inPubMed Google Scholar * PAUL B. CHRETIEN View author publications You can also search for this author inPubMed Google Scholar * EDWARD L.

FELIX View author publications You can also search for this author inPubMed Google Scholar * BETTY C. LOYD View author publications You can also search for this author inPubMed Google

Scholar * ALFRED S. KETCHAM View author publications You can also search for this author inPubMed Google Scholar * LELAND A. ALBRIGHT View author publications You can also search for this

author inPubMed Google Scholar * AYUB K. OMMAYA View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE COHEN, M., CHRETIEN, P., FELIX, E. _et al._ Augmentation of lymphocyte reactivity in guinea pigs, mice, monkeys and humans sensitised to BCG,

dinitrochlorobenzene or nitrogen mustard. _Nature_ 249, 656–658 (1974). https://doi.org/10.1038/249656a0 Download citation * Received: 13 February 1974 * Revised: 08 April 1974 * Issue Date:

14 June 1974 * DOI: https://doi.org/10.1038/249656a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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