Possible role for the fc receptor on b lymphocytes

ABSTRACT B LYMPHOCYTES1, polymorphonuclear cells2, mast cells3 and cells of the macrophage–monocyte2 series possess surface receptors for the Fc portion of the immunoglobulin molecule. In

some cases the functions of this receptor is clearly understood but this is not true for B lymphocytes. It has been suggested that the Fc receptor on B cells plays a role in the localisation

of antigen in the form of antigen–antibody complexes4. We propose an alternative hypothesis that the Fc receptor on B cells is a membrane receptor (termed the proreceptor) for the

immunoglobulin which functions as antigen receptor on these cells and present some evidence compatible with this hypothesis. Access through your institution Buy or subscribe This is a

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FC RECEPTOR RECOGNITION OF IMMUNOGLOBULIN M Article 24 April 2023 TOWARDS A UNIFYING MODEL FOR B-CELL RECEPTOR TRIGGERING Article 10 September 2024 IMMUNOGLOBULIN M PERCEPTION BY FCΜR

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Division, Department of Pathology, Tennis Court Road, Cambridge, UK RANJAN RAMASAMY & ALAN MUNRO * MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK CESAR MILSTEIN Authors *

RANJAN RAMASAMY View author publications You can also search for this author inPubMed Google Scholar * ALAN MUNRO View author publications You can also search for this author inPubMed 

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THIS ARTICLE RAMASAMY, R., MUNRO, A. & MILSTEIN, C. Possible role for the Fc receptor on B lymphocytes. _Nature_ 249, 573–574 (1974). https://doi.org/10.1038/249573a0 Download citation *

Received: 19 February 1974 * Issue Date: 07 June 1974 * DOI: https://doi.org/10.1038/249573a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:

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