Argbp2, encoding a negative regulator of abl, is fused to mll in a case of infant m5 acute myeloid leukemia involving 4q35 and 11q23

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Argbp2, encoding a negative regulator of abl, is fused to mll in a case of infant m5 acute myeloid leukemia involving 4q35 and 11q23"


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Access through your institution Buy or subscribe Children with acute myeloid leukemia (AML) in Italy have a probability of event-free survival of 53% at 5 years.1 Acute myeloid leukemia


associated with rearrangements involving the MLL gene (translocations, duplications, inversions, deletions) are frequently found in infants and in patients with secondary leukemias following


treatment with DNA topoisomerase-II inhibitors, and are most often associated with the AML-M5 or -M4 FAB subtypes.2 The MLL gene (also called ALL-1 or HRX), located at 11q23, is involved in


over 60 different translocations leading to gene fusion and over 30 partner genes have so far been cloned and partially characterized.2 The most common translocation is the t(9;11)(p22;q23)


giving rise to the MLL-AF9 fusion gene, while other recurring translocations are the t(11;19)(q23;p13.3) and the t(11;19)(q23;p13.1), producing, respectively, the MLL-ENL and MLL-ELL


oncogenes. Several studies have demonstrated that the transcriptional effector functions of the MLL fusion partners are essential for leukemogenesis; however, there are few common


characteristics among these partner proteins that can clarify their role in leukemogenesis.2 We report the identification of ArgBP2 (Arg-binding-protein-2) as a new partner gene of _MLL_ in


a case of infant AML. A 3-month-old girl was diagnosed as having AML-M5. Her peripheral blood mononuclear cell count was 131 × 106/ml. Peripheral blood and bone marrow smears showed 16 and


30% of blasts, respectively. Immunophenotypic analysis revealed that the leukemic blasts were highly positive (from 42 to 77%) for CD14, CD15, CD33 and C11b. This is a preview of


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* X83604 REFERENCES * Pession A, Rondelli R, Basso G, Rizzari C, Testi AM, Fagioli F _et al_. Treatment and long-term results in children with acute myeloid leukaemia treated according to


the AIEOP AML protocols. _Leukemia_ 2005; 19: 2043–2053. Article  CAS  Google Scholar  * Li ZY, Liu DP, Liang CC . New insight into the molecular mechanisms of MLL-associated leukemia.


_Leukemia_ 2005; 19: 183–190. Article  Google Scholar  * Felix CA, Jones DH . Panhandle PCR: a technical advance to amplify MLL genomic translocation breakpoints. _Leukemia_ 1998; 12:


976–981. Article  CAS  Google Scholar  * Megonigal MD, Rappaport EF, Wilson RB, Jones DH, Whitlock JA, Ortega JA _et al_. Panhandle PCR for cDNA: a rapid method for isolation of MLL fusion


transcripts involving unknown partner genes. _Proc Natl Acad Sci USA_ 2000; 97: 9597–9602. Article  CAS  Google Scholar  * Strehl S, Borkhardt A, Slany R, Fuchs UE, Konig M, Haas OA . The


human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). _Oncogene_ 2003; 22: 157–160. Article  CAS  Google Scholar  * Cestra G, Toomre D, Chang S, De Camilli P


. The Abl Arg substrate ArgBP2 nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton. _Proc Natl Acad Sci USA_ 2005; 102: 1731–1736. Article


  CAS  Google Scholar  * Soubeyran P, Barac A, Szymkiewicz I, Dikic I . Cbl–ArgBP2 complex mediates ubiquitination and degradation of c-Abl. _Biochem J_ 2003; 370: 29–34. Article  CAS 


Google Scholar  * Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD _et al_. ArgBP2 interacts with Akt and p21-activated kinase-1 and promotes cell survival. _J Biol Chem_ 2005; 280:


2183–2190. Google Scholar  Download references ACKNOWLEDGEMENTS This work was supported by grants from AIRC (to AP and LLN and a Regional Grant), MURST/FISR, and by the University of Bologna


(funds for selected research topics). LM and SS were supported by AGEOP. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, University of Bologna, Bologna, Italy A


Pession, L Montemurro, S Serravalle, R Fazzina & R Tonelli * Center of Pediatric Hematology Oncology, University of Catania, Catania, Italy L Lo Nigro * Division of Pediatrics, Hospital


of Parma, Parma, Italy G Izzi * Department of Pathology and Cancer Center, University of Illinois, Chicago, IL, USA G Nucifora * Department of Genetics, University of Erlangen, Erlangen,


Germany R Slany Authors * A Pession View author publications You can also search for this author inPubMed Google Scholar * L Lo Nigro View author publications You can also search for this


author inPubMed Google Scholar * L Montemurro View author publications You can also search for this author inPubMed Google Scholar * S Serravalle View author publications You can also search


for this author inPubMed Google Scholar * R Fazzina View author publications You can also search for this author inPubMed Google Scholar * G Izzi View author publications You can also


search for this author inPubMed Google Scholar * G Nucifora View author publications You can also search for this author inPubMed Google Scholar * R Slany View author publications You can


also search for this author inPubMed Google Scholar * R Tonelli View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to A


Pession. ADDITIONAL INFORMATION Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu) SUPPLEMENTARY INFORMATION SUPPLEMENTARY MATERIAL (DOC 19


KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pession, A., Lo Nigro, L., Montemurro, L. _et al._ ArgBP2, encoding a negative regulator of ABL, is


fused to MLL in a case of infant M5 acute myeloid leukemia involving 4q35 and 11q23. _Leukemia_ 20, 1310–1313 (2006). https://doi.org/10.1038/sj.leu.2404222 Download citation * Published: 20


April 2006 * Issue Date: 01 July 2006 * DOI: https://doi.org/10.1038/sj.leu.2404222 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get


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