No concomitant occurrence of the n-ras and p53 gene mutations in myelodysplastic syndromes

ABSTRACT Mutations of the N-ras oncogene and p53 tumor suppressor gene were simultaneously investigated in bone marrow cells from 44 patients with myelodysplastic syndrome (MDS) or

MDS-derived leukemia by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing. The mutations of the N-ras gene were detected only in two cases with

MDS-derived leukemia. Three patients with MDS-derived leukemia and one with refractory anemia with excess of blasts exhibited five mutations of the p53 gene. No concomitant mutations of both

genes were observed in our study, suggesting that alterations of both genes could play an important role in the progression of MDS in a non-cooperative manner. Access through your

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AUTHORS AND AFFILIATIONS * Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan K Mitani, A Hangaishi, S Ogawa, Y Kanda, Y Yazaki & H Hirai * Department

of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan N Imamura * Department of Developmental Biology and Oncology, Research

Institute for Radiation Biology and Medicine, Hiroshima University, Japan K Miyagawa Authors * K Mitani View author publications You can also search for this author inPubMed Google Scholar *

A Hangaishi View author publications You can also search for this author inPubMed Google Scholar * N Imamura View author publications You can also search for this author inPubMed Google

Scholar * K Miyagawa View author publications You can also search for this author inPubMed Google Scholar * S Ogawa View author publications You can also search for this author inPubMed 

Google Scholar * Y Kanda View author publications You can also search for this author inPubMed Google Scholar * Y Yazaki View author publications You can also search for this author inPubMed

 Google Scholar * H Hirai View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Mitani, K., Hangaishi, A., Imamura, N. _et al._ No concomitant occurrence of the N-ras and p53 gene mutations in myelodysplastic syndromes. _Leukemia_ 11, 863–865 (1997).

https://doi.org/10.1038/sj.leu.2400666 Download citation * Received: 03 February 1997 * Accepted: 24 February 1997 * Issue Date: 01 June 1997 * DOI: https://doi.org/10.1038/sj.leu.2400666

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clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * N-ras * p53 * gene mutation * myelodysplastic syndrome * SSCP