Meiotic chromosome alterations produced by progesterone

ABSTRACT ADMINISTRATION of progestins has been shown to suppress spermatogenesis in intact animals and humans, but the mechanisms involved have not been fully defined1–3. Using an adaptation

of the method of Eik-Nes4 we have shown that perfusion of the canine testis with progesterone causes alterations in the meiotic chromosomes—chiefly sticky degeneration and improper

spreading with clumping of the chromosomes. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access

through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink *

Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional

subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS AGE-ASSOCIATED ABERRATIONS OF THE CUMULUS-OOCYTE INTERACTION AND IN THE ZONA PELLUCIDA

STRUCTURE REDUCE FERTILITY IN FEMALE MICE Article Open access 24 December 2024 PARITY ASSOCIATES WITH CHROMOSOMAL DAMAGE IN UTERINE LEIOMYOMAS Article Open access 14 September 2021 BILATERAL

ORCHIECTOMY DETERIORATES THE STRUCTURE AND FUNCTION OF SEMINAL VESICLES IN A RAT MODEL Article 10 January 2023 REFERENCES * Ericsson, R. J., and Dutt, R. H., _Endocrinology_, 77, 203

(1965). Article  CAS  Google Scholar  * Heller, C. G., Moore, D. J., Paulsen, A., Nelson, W. O., and Laidlaw, W. M., _Fed. Proc._, 18, 1057 (1959). PubMed  CAS  Google Scholar  * Heller, C.

G., Laidlaw, W. M., Harvey, H. T., and Nelson, W. O., _Ann. NY Acad. Sci._, 71, 649 (1958). Article  ADS  CAS  Google Scholar  * Eik-Nes, K. B., _Endocrinology_, 71, 101 (1962). Article  CAS

  Google Scholar  * Heller, C. G., Nelson, W. O., Hill, I. B., Henderson, E., Maddock, W. O., Jungck, F. C., Paulsen, C. A., and Mortimore, G. E., _Fert. Steril._, 1, 415 (1950). Article 

CAS  Google Scholar  * Lacy, D., and Lofts, B., _Proc. Roy. Soc._, 162, 188 (1965). Article  ADS  CAS  Google Scholar  * Beaconsfield, P., and Ginsburg, J., _Lancet_, i, 592 (1968). * Carr,

D. H., _Lancet_, ii, 830 (1967). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine, Section of Endocrinology, University of Tennessee College of

Medicine, Memphis, Tennessee DOROTHY L. WILLIAMS, JOHN W. RUNYAN & A. AINSWORTH HAGEN Authors * DOROTHY L. WILLIAMS View author publications You can also search for this author inPubMed 

Google Scholar * JOHN W. RUNYAN View author publications You can also search for this author inPubMed Google Scholar * A. AINSWORTH HAGEN View author publications You can also search for

this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE WILLIAMS, D., RUNYAN, J. & HAGEN, A. Meiotic Chromosome

Alterations produced by Progesterone. _Nature_ 220, 1145–1147 (1968). https://doi.org/10.1038/2201145a0 Download citation * Received: 03 September 1968 * Revised: 24 October 1968 * Issue

Date: 14 December 1968 * DOI: https://doi.org/10.1038/2201145a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative