Normocalcaemia in relation to cortisone secretion

ABSTRACT THE hypercalcaemia which occurs in adrenalectomized animals or in patients with Cushing's disease treated by subtotal adrenalectomy has been thought to be the result of

antagonism between secretions from the adrenal gland and parathyroid hormone1. Because cortisone produces hypocalcaemia, this hormone was thought to be the adrenal factor that influenced

calcium homeostasis. A brief review of the history of these findings was given by Myers _et al._2, who investigated the subject further in adult adrenalectomized dogs. They reported the

development of hypercalcaemia in these animals when cortisone therapy was withdrawn; however, subsequent thyro-parathyroidectomy of the animals failed to prevent the hypercalcaemia of

adrenal insufficiency. Our attention was caught by the fact that the dogs studied by Myers _et al._ lacked secretions from both the thyroids and the parathyroids. It has been shown that

thyroxine and calcitonin, both coming from the thyroid gland, are important in mineral metabolism3,4. This report describes the results of a study designed to find out whether secretions

from the thyroid, alone or in conjunction with parathyroid hormone, are important in the development of the hypercalcaemia of cortisone lack. Access through your institution Buy or subscribe

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Article 06 October 2021 REFERENCES * Eliel, L. P., Thomsen, C., and Chanes, R., _J. Clin. Endocrinol._, 25, 457 (1965). Article  CAS  Google Scholar  * Myers, W. P. L., Rothschild, E. O.,

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Hosp._, 88, 440 (1951). PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Mayo Clinic and Mayo Foundation, Rochester, Minnesota JENIFER JOWSEY * Mayo

Graduate School of Medicine, University of Minnesota, Rochester, Minnesota GEORGE W. SIMONS Authors * JENIFER JOWSEY View author publications You can also search for this author inPubMed 

Google Scholar * GEORGE W. SIMONS View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE JOWSEY, J., SIMONS, G. Normocalcaemia in relation to Cortisone Secretion. _Nature_ 217, 1277–1279 (1968). https://doi.org/10.1038/2171277a0 Download citation * Received: 12

February 1968 * Issue Date: 30 March 1968 * DOI: https://doi.org/10.1038/2171277a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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