Dna during the development of the american sea urchin

ABSTRACT WE reported recently on the properties of the deoxyribonucleic acids isolated from the egg, sperm and adult diploid tissues of the American sea urchin, _Arbacia punctulata_1. It was

found that the DNA isolated from the two haploid cells had similar buoyant densities of 1.700 g/cm3. This can be taken to mean that the DNAs from these sources have identical base

compositions2. On the other hand, the DNA derived from adult diploid cells exhibited a buoyant density of 1.702 g/cm3. If this difference in the density values of the haploid and adult

diploid cells reflects a real shift in base composition, it is indeed a most unexpected finding. The current ideas concerning cellular development and differentiation are based on the belief

that just as the adult diploid cells derive from the original zygote by orderly mitotic division, so the DNA from the adult cell is derived from the fertilized egg by exact replicative

cycles. Because the DNAs of sperm and egg have identical base compositions, this belief would lead to the prediction that a diploid cell resulting from this union would contain DNA with a

correspondingly identical base composition. Implied in this concept is the hypothesis that cellular differentiation is not the result of changes in the DNA but rather that it is controlled

by histone-masking and/or “cytoplasmic regulators” which have now been equated with messenger RNA. Access through your institution Buy or subscribe This is a preview of subscription content,

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DEVELOPMENTAL GENE REGULATORY NETWORK IN _HELIOCIDARIS_ SEA URCHINS Article 20 October 2022 LIFE-CYCLE-COUPLED EVOLUTION OF MITOSIS IN CLOSE RELATIVES OF ANIMALS Article Open access 22 May

2024 GENOMIC INSIGHTS OF BODY PLAN TRANSITIONS FROM BILATERAL TO PENTAMERAL SYMMETRY IN ECHINODERMS Article Open access 10 July 2020 REFERENCES * Carden, G. A., III, Rosenkranz, S., and

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INFORMATION AUTHORS AND AFFILIATIONS * Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York H. S. ROSENKRANZ & G. A. CARDEN III * Marine

Biological Laboratory, Woods Hole, Massachusetts H. S. ROSENKRANZ & G. A. CARDEN III Authors * H. S. ROSENKRANZ View author publications You can also search for this author inPubMed 

Google Scholar * G. A. CARDEN III View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE ROSENKRANZ, H., CARDEN, G. DNA during the Development of the American Sea Urchin. _Nature_ 213, 1024–1025 (1967). https://doi.org/10.1038/2131024a0 Download citation * Issue

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